ChemSpider 2D Image | histosol | C21H27N3O5

histosol

  • Molecular FormulaC21H27N3O5
  • Average mass401.456 Da
  • Monoisotopic mass401.195068 Da
  • ChemSpider ID4447518

  • Double-bond stereo - Double-bond stereo

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(2Z)-2-Butendisäure --N-(4-methoxybenzyl)-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethandiamin (1:1) [German] [ACD/IUPAC Name]
1,2-Ethanediamine, N1-[(4-methoxyphenyl)methyl]-N2,N2-dimethyl-N1-2-pyridinyl-, (2Z)-2-butenedioate (1:1) [ACD/Index Name]
200-422-7 [EINECS]
59-33-6 [RN]
Acide (2Z)-2-butènedioïque - N-(4-méthoxybenzyl)-N',N'-diméthyl-N-(2-pyridinyl)-1,2-éthanediamine (1:1) [French] [ACD/IUPAC Name]
ANTHISAN
histosol [Wiki]
Mepyramine (maleate)
Mepyramine maleate
MFCD00069333 [MDL number]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

AI3-61433 [DBID]
EU-0100890 [DBID]
MLS000069668 [DBID]
NSC 3604 [DBID]
NSC3604 [DBID]
P5514_SIGMA [DBID]
Prestwick_634 [DBID]
SMR000058495 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Appearance:

      white crystalline powder OU Chemical Safety Data (No longer updated) More details

    • Stability:

      Combustible. Incompatible with strong oxidizing agents. OU Chemical Safety Data (No longer updated) More details

    • Toxicity:

      ORL-RAT LD50 36 mg kg-1, SCU-RAT LD50 150 mg kg-1, IPR-MUS LD50 102 mg kg-1, IVN-GPG LD50 24.4 mg kg-1 OU Chemical Safety Data (No longer updated) More details

    • Safety:

      Safety glasses, gloves, adequate ventilation. OU Chemical Safety Data (No longer updated) More details

    • Target Organs:

      Histamine Receptor antagonist TargetMol T1232

    • Bio Activity:

      7-TM Receptors Tocris Bioscience 660
      Biochemicals & small molecules/Agonists & activators Hello Bio [HB2622]
      Histamine H1 receptor TargetMol T1232
      Histamine H1 Receptors Tocris Bioscience 660
      Histamine Receptors Tocris Bioscience 660
      Neuroscience TargetMol T1232
      Receptors & Transporters/G protein coupled receptors/Histamine/H<sub>1</sub> Hello Bio [HB2622]
      Selective H<sub>1</sub> receptor inverse agonist Hello Bio [HB2622]
      Selective H<sub>1</sub> receptor inverse agonist. Selective for H<sub>1</sub> over H<sub>2</sub>, H<sub>3</sub> and H<sub>4</sub> receptors (K<sub>i</sub> values are 0.4 nM, 5.2, >10 and >10 &micro;M respectively). Also a potent KCNQ/M potassium channel blocker. Shows anti-allergic and neuroexcitatory actions. Blood-brain barrier permeable. Hello Bio [HB2622]
      Selective H1 inverse agonist Tocris Bioscience 0660, 660
      Selective inverse agonist for the H1 receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC50 = -7.94) and intracellular calcium mobilization. Sequesters Gq/11 protein, redu cing its availability for other receptors associated with the same signaling pathway. Tocris Bioscience 0660
      Selective inverse agonist for the H1 receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC50 = -7.94) and intracellular calcium mobilization. Sequesters Gq/11 protein, reducing its availability for other receptors associated with the same signaling pathway. Tocris Bioscience 660

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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