ChemSpider 2D Image | Astelin | C22H25Cl2N3O

Astelin

  • Molecular FormulaC22H25Cl2N3O
  • Average mass418.359 Da
  • Monoisotopic mass417.137482 Da
  • ChemSpider ID49103

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, hydrochloride (1:1) [ACD/Index Name]
1(2H)-phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride
253-720-4 [EINECS]
37932-96-0 [RN]
4-((4-Chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone hydrochloride
4-((4-Chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)phthalazin-1(2H)-one hydrochloride
4-(4-Chlorbenzyl)-2-(1-methyl-4-azepanyl)-1(2H)-phthalazinonhydrochlorid (1:1) [German] [ACD/IUPAC Name]
4-(4-Chlorbenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-onhydrochlorid
4-(4-Chlorobenzyl)-2-(1-méthyl-4-azépanyl)-1(2H)-phtalazinone, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
4-(4-Chlorobenzyl)-2-(1-methyl-4-azepanyl)-1(2H)-phthalazinone hydrochloride (1:1) [ACD/IUPAC Name]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

0L591QR10I [DBID]
UNII:0L591QR10I [DBID]
4834474 [DBID]
A 5610 [DBID]
A33K416J2W [DBID]
A-5610 [DBID]
D00659 [DBID]
E-0659 [DBID]
LS-109215 [DBID]
QGN83XMX5P [DBID]
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  • Experimental Physico-chemical Properties
  • Predicted Physico-chemical Properties
  • Miscellaneous

    • Appearance:

      solid OU Chemical Safety Data (No longer updated) More details

    • Stability:

      Incompatible with strong oxidizing agents. OU Chemical Safety Data (No longer updated) More details

    • Safety:

      Handle with caution. OU Chemical Safety Data (No longer updated) More details

    • Target Organs:

      Histamine Receptor antagonist TargetMol T0211, T0211L

    • Chemical Class:

      The hydrochloride salt of azelastine. ChEBI CHEBI:2951

    • Bio Activity:

      Azelastine HCl is a potent, second-generation, selective, histamine antagonist. MedChem Express
      Azelastine HCl is a potent, second-generation, selective, histamine antagonist.; Target: Histamine Receptor; Azelastine is a selective H(1)-receptor antagonist that inhibits histamine release and interferes with activation of several other mediators of allergic inflammation. MedChem Express HY-B0462
      Azelastine HCl is a potent, second-generation, selective, histamine antagonist.;Target: Histamine ReceptorAzelastine is a selective H(1)-receptor antagonist that inhibits histamine release and interferes with activation of several other mediators of allergic inflammation. Azelastine can inhibit CHMCs activation and release of IL-6, tryptase, and histamine. On an equimolar basis, azelastine was a more potent inhibitor than olopatadine [1]. Topical azelastine progressively improved itching and conjunctival redness in PAC patients compared to placebo and was at least as effective as levocabastine. Rapid relief is consistent with H(1)-receptor antagonist action, while continued improvement up to 6 weeks may be consistent with mechanisms involving other mediators of allergic inflammation [2]. Azelastine nasal spray was reported to control all rhinitis symptoms, including nasal congestion, regardless of rhinitis diagnosis during the 2-week study period. Patients with seasonal allergic rh MedChem Express HY-B0462
      GPCR/G protein MedChem Express HY-B0462
      GPCR/G protein; MedChem Express HY-B0462
      Histamine H1 receptor TargetMol T0211, T0211L
      Histamine Receptor MedChem Express HY-B0462
      Neuroscience TargetMol T0211, T0211L

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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