ChemSpider 2D Image | Tenofovir disoproxil fumarate | C23H34N5O14P

Tenofovir disoproxil fumarate

  • Molecular FormulaC23H34N5O14P
  • Average mass635.515 Da
  • Monoisotopic mass635.183960 Da
  • ChemSpider ID4911265
  • Double-bond stereo - Double-bond stereo

    defined stereocentres - 1 of 1 defined stereocentres


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(2E)-2-Butendisäure -bis{[(isopropoxycarbonyl)oxy]methyl}-({[(2R)-1-(6-amino-9H-purin-9-yl)-2-propanyl]oxy}methyl)phosphonat (1:1) [German] [ACD/IUPAC Name]
(2E)-But-2-endisäure-bis({[(1-methylethoxy)carbonyl]oxy}methyl)-{[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl}phosphonat(1:1) [German]
(2E)-BUT-2-ENEDIOIC ACID; BIS({[(PROPAN-2-YLOXY)CARBONYL]OXY}METHYL) {[(2R)-1-(6-AMINO-9H-PURIN-9-YL)PROPAN-2-YL]OXY}METHANEPHOSPHONATE
202138-50-9 [RN]
9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine Fumarate
Acide (2E)-2-butènedioïque - ({[(2R)-1-(6-amino-9H-purin-9-yl)-2-propanyl]oxy}méthyl)phosphonate de bis{[(isopropoxycarbonyl)oxy]méthyle} (1:1) [French] [ACD/IUPAC Name]
acide (2E)-but-2-ènedioïque - {[(1R)-2-(6-amino-9H-purin-9-yl)-1-méthyléthoxy]méthyl}phosphonate de bis({[(1-méthyléthoxy)carbonyl]oxy}méthyle) (1:1)
Bis(((isopropoxycarbonyl)oxy)methyl) (((1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy)methyl)phosphonate (2E)-2-Butenedioate
bis({[(1-methylethoxy)carbonyl]oxy}methyl) {[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl}phosphonate (2E)-but-2-enedioate
bis({[(propan-2-yloxy)carbonyl]oxy}methyl) ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonate (2E)-but-2-enedioate (1:1)
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CHEBI:63718 [DBID]
D01982 [DBID]
GS-1278 [DBID]
HSDB 7165 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Chemical Class:

      A fumarate salt prepared from equimolar amounts of tenofovir disoproxil and fumaric acid. It is used in combination therapy for the treatment of HIV infection. ChEBI CHEBI:63718
    • Bio Activity:

      Anti-infection MedChem Express HY-13782
      Anti-infection; MedChem Express HY-13782
      HIV MedChem Express HY-13782
      HIV NRTIs MedChem Express HY-13782
      Tenofovir(GS 1278, PMPA) is an antiretroviral drug known as nucleotide analogue reverse transcriptase inhibitors (NRTIs), which block reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV.; IC50 Value:0.5-2.2 uM (HIV-1); 1.6-4.9 uM (HIV-2) [1]; Target: NRTIs; in vitro: Tenofovir hydrate reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 ?g/mL, 1.12 ?g/mL and 1.05 ?g/mL in MT-4 cells. MedChem Express HY-13782

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site






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