ChemSpider 2D Image | Sunitinib malate | C26H33FN4O7

Sunitinib malate

  • Molecular FormulaC26H33FN4O7
  • Average mass532.561 Da
  • Monoisotopic mass532.233337 Da
  • ChemSpider ID4958254

  • Double-bond stereo - Double-bond stereo

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(2S)-2-Hydroxybernsteinsäure --N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluor-2-oxo-1,2-dihydro-3H-indol-3-yliden)methyl]-2,4-dimethyl-1H-pyrrol-3-carboxamid (1:1) [German] [ACD/IUPAC Name]
(2S)-2-hydroxybutanedioic acid; N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide
(2S)-2-Hydroxysuccinic acid - N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1) [ACD/IUPAC Name]
341031-54-7 [RN]
Acide (2S)-2-hydroxysuccinique - N-[2-(diéthylamino)éthyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidène)méthyl]-2,4-diméthyl-1H-pyrrole-3-carboxamide (1:1) [French] [ACD/IUPAC Name]
Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1) [ACD/Index Name]
LVX8N1UT73
MFCD08282795 [MDL number]
N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioic acid (1:1) salt
N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioate salt
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

SU 011248 [DBID]
SU 11248 [DBID]
SU-010398 [DBID]
SU-11248 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold for research purposes under agreement from Pfizer Inc. Tocris Bioscience 3768

    • Target Organs:

      c-Kit inhibitor; PDGFR inhibitor; VEGFR inhibitor TargetMol T0374

    • Bio Activity:

      c-Kit;PDGFR??;VEGFR2 TargetMol T0374
      Enzyme-Linked Receptors Tocris Bioscience 3768
      PDGFR MedChem Express HY-10255
      PDGFR VEGFR MedChem Express HY-10255
      Potent VEGFR, PDGFR? and KIT inhibitor Tocris Bioscience 3768
      Potent VEGFR, PDGFRbeta and KIT inhibitor Tocris Bioscience 3768
      Potent, ATP-competitive VEGFR, PDGFR? and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFR? and KIT respectively). Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models. Tocris Bioscience 3768
      Potent, ATP-competitive VEGFR, PDGFR? and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFR? and KIT respectively). Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models. Tocris Bioscience 3768
      Potent, ATP-competitive VEGFR, PDGFRbeta and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRbeta and KIT respectively). Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models. Tocris Bioscience 3768
      Protein Tyrosine Kinase/RTK MedChem Express HY-10255
      Protein Tyrosine Kinase/RTK; MedChem Express HY-10255
      Receptor Tyrosine Kinases (RTKs) Tocris Bioscience 3768
      Sunitinib(SU-11248; Sutent) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFR? with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.; IC50 Value: 2 nM (PDGFR?); 80 nM (VEGFR2) [1]; Target: PDGFR?; VEGFR2; in vitro: Sunitinib is a potent ATP-competitive inhibitor of VEGFR2 (Flk1) and PDGFR? with Ki of 9 nM and 8 nM, respectively, displaying >10-fold higher selectivity for VEGFR2 and PDGFR than FGFR-1, EGFR, Cdk2, Met, IGFR-1, Abl, and src. MedChem Express HY-10255
      Tyrosine Kinase/Adaptors TargetMol T0374
      VEGFR Tocris Bioscience 3768

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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