ChemSpider 2D Image | cetirizine dihydrochloride | C21H27Cl3N2O3

cetirizine dihydrochloride

  • Molecular FormulaC21H27Cl3N2O3
  • Average mass461.810 Da
  • Monoisotopic mass460.108734 Da
  • ChemSpider ID49830

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

cetirizine dihydrochloride
(2-{4-[(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}ethoxy)acetic acid dihydrochloride [ACD/IUPAC Name]
(2-{4-[(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid dihydrochloride
(2-{4-[(4-Chlorphenyl)(phenyl)methyl]-1-piperazinyl}ethoxy)essigsäuredihydrochlorid [German] [ACD/IUPAC Name]
(2-{4-[(4-Chlorphenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)essigsäuredihydrochlorid
[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride
83881-52-1 [RN]
acetic acid, [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride
Acetic acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, hydrochloride (1:2) [ACD/Index Name]
Acide (2-{4-[(4-chlorophényl)(phényl)méthyl]-1-pipérazinyl}éthoxy)acétique, dichlorhydrate [French] [ACD/IUPAC Name]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

64O047KTOA [DBID]
UNII:64O047KTOA [DBID]
4792TC1585 [DBID]
D00664 [DBID]
LS-11411 [DBID]
P 071 [DBID]
P-071 [DBID]
Prestwick_841 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      Histamine Receptor antagonist TargetMol T0089

    • Bio Activity:

      7-TM Receptors Tocris Bioscience 2577
      Cetirizine 2Hcl, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. MedChem Express HY-17042A
      Cetirizine 2Hcl, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. ;IC50 value:;Target: Histamine H1 receptorCetirizine crosses the blood-brain barrier only slightly, reducing the sedative side-effect common with older antihistamines. It has also been shown to inhibit eosinophil chemotaxis and LTB4 release. At a dosage of 20 mg, Boone et al. found that it inhibited the expression of VCAM-1 in patients with atopic dermatitis. The levorotary enantiomer of cetirizine, known as levocetirizine, is the more active form. From Wikipedia. MedChem Express HY-17042A
      Cetirizine 2Hcl, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. MedChem Express
      GPCR/G protein MedChem Express HY-17042A
      GPCR/G protein; MedChem Express HY-17042A
      Histamine H1 receptor TargetMol T0089
      Histamine H1 receptor antagonist that displays selectivity over other receptors at concentrations up to 10 ?M. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis du ring secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo. Tocris Bioscience 2577
      Histamine H1 receptor antagonist that displays selectivity over other receptors at concentrations up to 10 ?M. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo. Tocris Bioscience 2577
      Histamine H1 receptor antagonist that displays selectivity over other receptors at concentrations up to 10 muM. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo. Tocris Bioscience 2577
      Histamine H1 Receptors Tocris Bioscience 2577
      Histamine Receptor MedChem Express HY-17042A
      Histamine Receptors Tocris Bioscience 2577
      Neuroscience TargetMol T0089
      Selective H1 antagonist Tocris Bioscience 2577

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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