ChemSpider 2D Image | fosbretabulin disodium | C18H19Na2O8P

fosbretabulin disodium

  • Molecular FormulaC18H19Na2O8P
  • Average mass440.292 Da
  • Monoisotopic mass440.061279 Da
  • ChemSpider ID5293513

  • Charge - Charge

    Double-bond stereo - Double-bond stereo

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl disodium phosphate
702RHR475O
Combretastatin A4 disodium phosphate
Combretastatin A4 phosphate disodium
Dinatrium-2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenylphosphat [German] [ACD/IUPAC Name]
disodium 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl phosphate
Disodium 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenyl phosphate [ACD/IUPAC Name]
fosbretabulin disodium [USAN]
Fosbretabulin disodium salt
Fosbretabulin sodium
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

222030-63-9 [DBID] [RN]
CA4DP [DBID]
CA4P [DBID]
BRN 1907120 [DBID]
CA-4P [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Cell Cycle/DNA Damage MedChem Express HY-17449
      Cell Cycle/DNA Damage; MedChem Express HY-17449
      Fosbretabulin disodium(CA 4DP; CA 4P) is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing centra l necrosis. MedChem Express
      Fosbretabulin disodium(CA 4DP; CA 4P) is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis.; IC50 Value: 4 nM [1]; Target: microtubule; in vitro: Cytotoxic IC(50) values of CA-4 in human bladder cancer cells were below 4 nM. MedChem Express HY-17449
      Fosbretabulin disodium(CA 4DP; CA 4P) is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis.;IC50 Value: 4 nM [1];Target: microtubule;In vitro: Cytotoxic IC(50) values of CA-4 in human bladder cancer cells were below 4 nM. Analyses of cell-cycle distribution showed CA-4 obviously induced G(2)-M phase arrest with sub-G(1) formation. The analyses of apoptosis showed that CA-4 induced caspase-3 activation and decreased BubR1 and Bub3 in cancer cells [1]. The enhanced apoptosis induced by dasatinib plus CA-4 was accompanied by a greater extent of mitochondrial depolarization, caspase-3 activation and PARP cleavage in HO-8910 cells. Furthermore, elevated expression of Mcl-1 led to a reduced apoptosis induced by dasatinib plus CA-4, highlighting that downregulated Mcl-1 was necessary for the potentiating effect of dasatinib to CA-4-triggered apoptosis [2].;In vivo: The MedChem Express HY-17449
      Microtubule/Tubulin MedChem Express HY-17449

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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