ChemSpider 2D Image | GR 38032F | C18H24ClN3O3

GR 38032F

  • Molecular FormulaC18H24ClN3O3
  • Average mass365.854 Da
  • Monoisotopic mass365.150604 Da
  • ChemSpider ID53922

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

103639-04-9 [RN]
4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-, hydrochloride, hydrate (1:1:2) [ACD/Index Name]
693-98-1 [RN]
9-Methyl-3-((2-methylimidazol-1-yl)methyl)-2,3-dihydro-1H-carbazol-4-one hydrochloride 2H2O
9-Methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride dihydrate [ACD/IUPAC Name]
9-Méthyl-3-[(2-méthyl-1H-imidazol-1-yl)méthyl]-1,2,3,9-tétrahydro-4H-carbazol-4-one, chlorhydrate, dihydrate [French] [ACD/IUPAC Name]
9-Methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-onhydrochloriddihydrat [German] [ACD/IUPAC Name]
GR 38032F
MFCD00374371 [MDL number]
Ondansetron hydrochloride dihydrate
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

FE6375500 [DBID]
NMH84OZK2B [DBID]
UNII:NMH84OZK2B [DBID]
D00678 [DBID]
GG-032 [DBID]
GR 38032 [DBID]
GR 38032X [DBID]
GR-38032F [DBID]
NSC 665799 [DBID]
SN 307 [DBID]
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  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      5-HT Receptor antagonist; Opioid Receptor TargetMol T1478

    • Bio Activity:

      5-HT Receptor MedChem Express HY-B0002A
      5-HT Receptor???Mu-type opioid receptor TargetMol T1478
      GPCR/G protein MedChem Express HY-B0002A
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-B0002A
      Neuroscience TargetMol T1478
      Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy. MedChem Express
      Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.; Target: 5- HT3 Receptor; IC50 Value: ; in vitro: 5-HT evoked transient inward currents (EC50 = 3.4 microM; Hill coefficient = 1.8) that were blocked by the 5-HT3 receptor antagonist ondansetron (IC50 = 103 pM) [1]. MedChem Express HY-B0002A
      Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.;Target: 5- HT3 Receptor;IC50 Value: ;In vitro: 5-HT evoked transient inward currents (EC50 = 3.4 microM; Hill coefficient = 1.8) that were blocked by the 5-HT3 receptor antagonist ondansetron (IC50 = 103 pM) [1]. The 5-HT3A receptor antagonist ondansetron (0.3 nM) reversibly inhibited the 5-HT (30 microM) signal by 70% and at 3 nM it abolished the response [2].;In vivo: Acute ondansetron administration at the lowest dose (0.1 mg/kg, IP) tested had no effect, while other doses (0.33 and 1 mg/kg, IP) produced improvements in auditory gating [3]. Different doses of ondansetron were injected intraperitoneally (i.p.) at fixed times during the day to determine both the sublethal (TD50) and lethal (LD50) doses, which were, respectively, 3.7 +/- 0.6 mg/kg and 4.6 +/- 0.5 mg/kg [4]. ondansetron (0.25-1.0 mg/kg, subcutaneously) given before the chall MedChem Express HY-B0002A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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