ChemSpider 2D Image | (S)-duloxetine hydrochloride | C18H20ClNOS

(S)-duloxetine hydrochloride

  • Molecular FormulaC18H20ClNOS
  • Average mass333.875 Da
  • Monoisotopic mass333.095398 Da
  • ChemSpider ID54821

  • defined stereocentres - 1 of 1 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(S)-duloxetine hydrochloride
(+)-(S)-N-methyl-g-(1-naphthyloxy)-2-thiophenepropylamine Hydrochloride
(+)-(S)-N-Methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride
(+)-N-Methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine hydrochloride
(3S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride (1:1) [ACD/IUPAC Name]
(3S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanaminhydrochlorid (1:1) [German] [ACD/IUPAC Name]
(3S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine hydrochloride (1:1)
(3S)-N-Méthyl-3-(1-naphtyloxy)-3-(2-thiényl)-1-propanamine, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
(3S)-N-méthyl-3-(naphtalén-1-yloxy)-3-thiophén-2-ylpropan-1-amine chlorhydrate
(3S)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride (1:1)
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

116539-59-4, 136434-34-9 [DBID]
CHEBI:31526 [DBID]
D01179 [DBID]
LS-172959 [DBID]
LY-248686 [DBID]
LY-264453 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      A duloxetine hydrochloride in which the duloxetine moiety has <stereo>S</stereo> configuration. ChEBI CHEBI:31526
      A duloxetine hydrochloride in which the duloxetine moiety has S configuration. ChEBI CHEBI:31526

    • Bio Activity:

      5-HT Transporters Tocris Bioscience 4798
      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio HB1806
      Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). MedChem Express
      Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).; Target: SNRI; Duloxetine (sold under the brand names Cymbalta, Ariclaim, Xeristar, Yentreve, Duzela, Dulane) is a serotonin-norepinephrine reuptake inhibitor(SNRI) manufactured and marketed by Eli Lilly. MedChem Express HY-B0161A
      Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).;Target: SNRIDuloxetine (sold under the brand names Cymbalta, Ariclaim, Xeristar, Yentreve, Duzela, Dulane) is a serotonin-norepinephrine reuptake inhibitor(SNRI) manufactured and marketed by Eli Lilly. It is prescribed for major depressive disorder and generalized anxiety disorder (GAD). Duloxetine also has approval for use in osteoarthiritis and musculoskeletal pain. Duloxetine failed the US approval for stress urinary incontinence amidst concerns over liver toxicity and suicidal events; however, it was approved for this indication in Europe, where it is recommended as an add-on medication in stress urinary incontinence instead of surgery. It can also relieve the symptoms of painful peripheral neuropathy, particularly diabetic neuropathy, and it is used to control the symptoms of fibromyalgia.;T MedChem Express HY-B0161A
      High affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC50 values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (Ki = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable. Tocris Bioscience 4798
      High affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC50 values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (Ki = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable . Tocris Bioscience 4798
      Neuronal Signaling MedChem Express HY-B0161A
      Neuronal Signaling; MedChem Express HY-B0161A
      Neurotransmitter Transporters Tocris Bioscience 4798
      Potent 5-HT and NA reuptake inhibitor. Also inhibits dopamine reuptake. Hello Bio HB1806
      Potent 5-HT and NA reuptake inhibitor; also blocks dopamine reuptake Tocris Bioscience 4798
      Receptors & Transporters/Transporters/5-HT uptake & transport Hello Bio HB1806
      SSRIs MedChem Express HY-B0161A
      Transporters Tocris Bioscience 4798

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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