ChemSpider 2D Image | (+)-Irinotecan | C33H38N4O6

(+)-Irinotecan

  • Molecular FormulaC33H38N4O6
  • Average mass586.678 Da
  • Monoisotopic mass586.279114 Da
  • ChemSpider ID54825

  • defined stereocentres - 1 of 1 defined stereocentres

More details:

Featured data source
The Merck Index Online

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(+)-Irinotecan
(4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]chinolin-9-yl-1,4'-bipiperidin-1'-carboxylat [German] [ACD/IUPAC Name]
(4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate [ACD/IUPAC Name]
[1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester [ACD/Index Name]
1,4'-Bipipéridine-1'-carboxylate de (4S)-4,11-diéthyl-4-hydroxy-3,14-dioxo-3,4,12,14-tétrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoléin-9-yle [French] [ACD/IUPAC Name]
97682-44-5 [RN]
Campto [Trade name]
Irinotecan [BAN] [INN] [Wiki]
irinotecán [Spanish] [INN]
irinotécan [French] [INN]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

6694 [DBID]
7673326042 [DBID]
AIDS108177 [DBID]
AIDS-108177 [DBID]
CPT-11 [DBID]
NCI60_005051 [DBID]
PubChem Substance ID 24891849 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      L01XX19 Wikidata Q412197
      Safety glasses. OU Chemical Safety Data (No longer updated) More details

    • Chemical Class:

      A member of the class of pyranoindolizinoquinolines that is the carbamate ester obtained by formal condensation of the carboxy group of [1,4'-bipiperidine]-1'-carboxylic acid with the phenolic hydroxy group of (4<stereo>S</stereo>)-4,11-diethyl-4,9-dihydroxy-1<element>H</element>-pyrano[3',4':6,7]indolizino[1,2- hydrochloride]quinoline-3,14-dione. Used (in the form of its hydrochloride salt trihyd rate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active. ChEBI CHEBI:80630
      A member of the class of pyranoindolizinoquinolines that is the carbamate ester obtained by formal condensation of the carboxy group of [1,4'-bipiperidine]-1'-carboxylic acid with the phenolic hydroxy group of (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2- hydrochloride]quinoline-3,14-dione. Used (in the form of its hydrochloride salt trihydrate) in combination with fluorourac il and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the car bamate linkage to its active metabolite, SN-38, which is ~1000 times more active. ChEBI CHEBI:80630

    • Bio Activity:

      Cell Cycle/DNA Damage MedChem Express HY-16562
      Cell Cycle/DNA Damage; MedChem Express HY-16562
      Irinotecan(CPT-11) prevents DNA from unwinding by inhibition of topoisomerase 1.; IC50 Value: 15.8 ?M(LoVo cells); 5.17 ?M(HT-29 cells); Target: Topoisomerase I; in vitro: Irinotecan is activated to SN-38 by carboxylesterases to become able to interact with its target, topoisomerase I. MedChem Express HY-16562
      Topoisomerase MedChem Express HY-16562

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point: 873.4±65.0 °C at 760 mmHg
Vapour Pressure: 0.0±0.3 mmHg at 25°C
Enthalpy of Vaporization: 133.0±3.0 kJ/mol
Flash Point: 482.0±34.3 °C
Index of Refraction: 1.689
Molar Refractivity: 159.1±0.4 cm3
#H bond acceptors: 10
#H bond donors: 1
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 2
ACD/LogP: 4.35
ACD/LogD (pH 5.5): 0.68
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 2.18
ACD/LogD (pH 7.4): 2.14
ACD/BCF (pH 7.4): 10.17
ACD/KOC (pH 7.4): 63.00
Polar Surface Area: 113 Å2
Polarizability: 63.1±0.5 10-24cm3
Surface Tension: 74.2±5.0 dyne/cm
Molar Volume: 416.8±5.0 cm3

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