ChemSpider 2D Image | Miglustat HCl | C10H22ClNO4

Miglustat HCl

  • Molecular FormulaC10H22ClNO4
  • Average mass255.739 Da
  • Monoisotopic mass255.123734 Da
  • ChemSpider ID571492

  • defined stereocentres - 4 of 4 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triol hydrochloride (1:1)
210110-90-0 [RN]
3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-, chloride, hydrogen salt, (2R,3R,4R,5S)- (1:1) [ACD/Index Name]
3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-, hydrochloride (1:1), (2R,3R,4R,5S)-
Chlorure d'hydrogène (2R,3R,4R,5S)-1-butyl-2-(hydroxyméthyl)-3,4,5-pipéridinetriol (1:1:1) [French] [ACD/IUPAC Name]
Hydrogen chloride (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol (1:1:1) [ACD/IUPAC Name]
Hydrogenchlorid-(2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)-3,4,5-piperidintriol (1:1:1) [German] [ACD/IUPAC Name]
Miglustat HCl
N-Butyldeoxynojirimycin (hydrochloride)
(2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol hydrochloride
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

B8299_SIGMA [DBID]
MLS000069516 [DBID]
SMR000058560 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      ?-glucosidase I and II inhibitor. Also inhibits ceramide-specific glycosyltransferases Tocris Bioscience 3117
      alpha-glucosidase I and II inhibitor. Also inhibits ceramide-specific glycosyltransferases Tocris Bioscience 3117
      Enzymes Tocris Bioscience 3117
      Glycosylases Tocris Bioscience 3117
      Miglustat hydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1). MedChem Express
      Miglustat hydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).; Target: Others; Miglustat is an inhibitor of the ceramide-specific glycosyltransferase, which catalyzes the first step of glycosphingolipid biosynthesis and is currently approved for the oral treatment of type 1 GD [1]. MedChem Express HY-17020A
      Miglustat hydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).;Target: Miglustat is an inhibitor of the ceramide-specific glycosyltransferase, which catalyzes the first step of glycosphingolipid biosynthesis and is currently approved for the oral treatment of type 1 GD [1]. Consumption of a standard high-fat breakfast within 30 minutes before administration of miglustat significantly reduced peak exposure but did not significantly affect the extent of systemic exposure to miglustat. The peak plasma concentration (C(max)) decreased by 36% on average following administration with food. Area under the plasma concentration-time curve (AUC(0-infinity)) showed a modest (14%) decrease with food, but the 90% confidence interval was within the acceptance limit of 80% to 125%. The median (min-max) time to C(max) (t(max)) was prolonged from 2.5 (1.0-4.0) hours in the fasted state to 4.5 (1.5-8.0) hours in the fed state, whereas the MedChem Express HY-17020A
      Orally active ?-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER ?-glucosidase s I and II. Also has broad spectrum antiviral activity. Tocris Bioscience 3117
      Orally active ?-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER ?-glucosidases I and II. Also has broad spectrum antiviral activity. Tocris Bioscience 3117
      Orally active alpha-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER alpha-glucosidases I and II. Also has broad spectrum antiviral activity. Tocris Bioscience 3117
      Orally active alpha-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER alpha-glucosidases I and II. Also has broad spectrum antiviral activity. Deuterated analog also available. Tocris Bioscience 3117
      Others MedChem Express HY-17020A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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