ChemSpider 2D Image | TP-064 | C28H34N4O2

TP-064

  • Molecular FormulaC28H34N4O2
  • Average mass458.595 Da
  • Monoisotopic mass458.268188 Da
  • ChemSpider ID58830972

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

2080306-20-1 [RN]
Benzamide, N-methyl-N-[[2-[1-[2-(methylamino)ethyl]-4-piperidinyl]-4-pyridinyl]methyl]-3-phenoxy- [ACD/Index Name]
N-Methyl-N-[(2-{1-[2-(methylamino)ethyl]-4-piperidinyl}-4-pyridinyl)methyl]-3-phenoxybenzamid [German] [ACD/IUPAC Name]
N-Methyl-N-[(2-{1-[2-(methylamino)ethyl]-4-piperidinyl}-4-pyridinyl)methyl]-3-phenoxybenzamide [ACD/IUPAC Name]
N-Méthyl-N-[(2-{1-[2-(méthylamino)éthyl]-4-pipéridinyl}-4-pyridinyl)méthyl]-3-phénoxybenzamide [French] [ACD/IUPAC Name]
N-Methyl-N-[(2-{1-[2-(Methylamino)ethyl]piperidin-4-Yl}pyridin-4-Yl)methyl]-3-Phenoxybenzamide
TP-064
7VM
CARM1
N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TP 064 probe summary on the SGC website. Tocris Bioscience 6008

    • Bio Activity:

      Enzymes Tocris Bioscience 6008
      Potent and selective PRMT 4 inhibitor Tocris Bioscience 6008
      Potent and selective PRMT4 inhibitor; inhibits methylation of H3 (1-25) and MED12 (IC50 values are <10 and 43 nM, respectively). Exhibits >100-fold selectivity over other histone methyltransferases and non-epigenetic targets. Tocris Bioscience 6008
      Protein Arginine Methyltransferases Tocris Bioscience 6008
      Transferases Tocris Bioscience 6008

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.1±0.1 g/cm3
Boiling Point: 642.8±55.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.9 mmHg at 25°C
Enthalpy of Vaporization: 94.9±3.0 kJ/mol
Flash Point: 342.5±31.5 °C
Index of Refraction: 1.588
Molar Refractivity: 136.0±0.3 cm3
#H bond acceptors: 6
#H bond donors: 1
#Freely Rotating Bonds: 9
#Rule of 5 Violations: 0
ACD/LogP: 2.56
ACD/LogD (pH 5.5): -0.60
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): 0.62
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 2.74
Polar Surface Area: 58 Å2
Polarizability: 53.9±0.5 10-24cm3
Surface Tension: 47.0±3.0 dyne/cm
Molar Volume: 404.4±3.0 cm3

Click to predict properties on the Chemicalize site


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