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Telmisartan

Molecular FormulaC₃₃H₃₀N₄O₂
Average mass514.617 Da
Monoisotopic mass514.236877 Da
ChemSpider ID59391

More details:

Featured data source

Names and Synonyms
Database ID(s)

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

[1,1'-Biphenyl]-2-carboxylic acid, 4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]- [ACD/Index Name]

144701-48-4 [RN]

4'[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid

4'-[(1,7'-Dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]-2-biphenylcarbonsäure [German] [ACD/IUPAC Name]

4'-[(1,7'-Dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]-2-biphenylcarboxylic acid [ACD/IUPAC Name]

4'-[(1,7'-Dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carbonsäure [German]

4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid

Acide 4'-[(1,7'-diméthyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)méthyl]-2-biphénylcarboxylique [French] [ACD/IUPAC Name]

acide 4'-[(1,7'-diméthyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)méthyl]biphényl-2-carboxylique [French]

Kinzalmono [Trade name]

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MFCD00918125 [MDL number]

Micardis [Trade name]

Pritor [Trade name]

telmisartan [French] [INN]

Telmisartan [INN] [JAN] [USAN] [Wiki]

telmisartán [Spanish] [INN]

telmisartanum [Latin] [INN]

U5SYW473RQ

телмисартан [Russian] [INN]

تيلميسارتان [Arabic] [INN]

替米沙坦 [Chinese] [INN]

(1,1'-Biphenyl)-2-carboxylic acid, 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-

[1,1'-biphenyl]-2-carboxylic acid, 4'[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]

[144701-48-4] [RN]

1189889-44-8 [RN]

1794754-60-1 [RN]

2-(4-{[4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}phenyl)benzoic acid

2-[4-[[4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl]methyl]phenyl]benzoic acid

2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid

2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propyl-benzimidazol-1-yl]methyl]phenyl]benzoic acid

2-[4-[[4-methyl-6-(1-methylbenzoimidazol-2-yl)-2-propyl-benzoimidazol-1-yl]methyl]phenyl]benzoic acid

4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid

4-((1,7-dimethyl-2-propyl-1h,3h-[2,5-bibenzo[d]imidazol]-3-yl)methyl)-[1,1-biphenyl]-2-carboxylic acid

4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid

4'-((4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid

4-(1,4-Dimethyl-2-propyl-2,6-bi-1H-benzimidazol-1-yl)methyl-1,1-biphenyl-2-carboxylicacid

4'-(1,7'-Dimethyl-2'-propyl-1H-[2,5']bibenzoimidazolyl-3'-ylmethyl)-biphenyl-2-carboxylic acid

4'-?[(1,?4'-?DIMETHYL-?2'-?PROPYL[2,?6'-?BI-?1H-?BENZIMIDAZOL]-?1'-?YL)METHYL]-?[1,?1'-?BIPHENYL]-?2-?CARBOXYLIC ACID

4'-[(1,4'-dimethyl-2'propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid

4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid

4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid

4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid

4-[(1,7-dimethyl-2-propyl-1h,3h-2,5-bibenzimidazol-3-yl)methyl]biphenyl-2-carboxylic acid

4'[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid

4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester

4'-[[4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl]methyl]-2-biphenylcarboxylic acid

4'-{[4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}-[1,1'-biphenyl]-2-carboxylic acid

6624054 [Beilstein]

BAY-68-9291

BIBR 277 SE

BIBR 277;Micardis;Pritor;Telday

BIBR 277SE

BIBR277

BIBR-277SE

BIBR-277-SE

BR-72892

BSPBio_002738

Carbon monoxide releasing molecule 3 |

DB00966

DV2037500

Kinzal

KS-1215

Micardis (TN)

MICARDIS HCT

Micardis®

MLS000759432

NCGC00095150-01

NCGC00095150-02

Pharmakon1600-01505261

Pritor®

SMR000466326

SPECTRUM1505261

Spectrum5_001053

Targit

Targit;Temax;BIBR277;Micardis

Telday

Teleact D

Telma

telmisartán

Telmisartan (JAN/USAN/INN)

Telmisartan (Micardis)

TELMISARTAN-D3

Telmisartan-d7

telmisartanum

Telmisattan

Temax

TL8000991

TLS

UNII:U5SYW473RQ

UNII-U5SYW473RQ

телмисартан

تيلميسارتان

替米沙坦

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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

7144 [DBID]

BIBR 277 [DBID]

BIBR-277 [DBID]

C07710 [DBID]

D00627 [DBID]

KBio3_001958 [DBID]

KBioGR_001842 [DBID]

LS-44263 [DBID]

SPBio_002131 [DBID]

Spectrum2_001976 [DBID]

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Experimental data
Predicted - ACD/Labs
Predicted - ChemAxon
Predicted - Mcule

Experimental Physico-chemical Properties

Experimental Melting Point:

262 °C Jean-Claude Bradley Open Melting Point Dataset 16428

Experimental Solubility:

Miscellaneous

Safety:

C09CA07 Wikidata Q733186
Target Organs:

RAAS inhibitor; ACE inhibitor; PPAR agonist TargetMol T1570
Chemical Class:

A member of the class of benzimidazoles used widely in the treatment of hypertension. ChEBI CHEBI:9434

Bio Activity:

7-TM Receptors Tocris Bioscience 5139

ACE;PPAR gamma TargetMol T1570

Angiogenesis; Endocrinology/ Hormones TargetMol T1570

Angiotensin Receptor MedChem Express HY-13955

Angiotensin Receptors Tocris Bioscience 5139

Antagonist of the angiotensin II type 1 receptor (AT1) (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPAR? receptors; shown to improv e insulin sensitivity in rodents receiving high fat diets. Tocris Bioscience 5139

Antagonist of the angiotensin II type 1 receptor (AT1) (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPAR? receptors; shown to improve insulin sensitivity in rodents receiving high fat diets. Tocris Bioscience 5139

Antagonist of the angiotensin II type 1 receptor (AT1) (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPARgamma receptors; shown to improve insulin sensitivity in rodents receiving high fat diets. Tocris Bioscience 5139

AT1 antagonist; PPAR? partial agonist Tocris Bioscience 5139

AT1 antagonist; PPARgamma partial agonist Tocris Bioscience 5139

GPCR/G protein MedChem Express HY-13955

GPCR/G protein; MedChem Express HY-13955

Peptide Receptors Tocris Bioscience 5139

Telmisartan(BIBR 277) is an angiotensin II receptor antagonist (angiotensin receptor blocker, ARB) used in the management of hypertension. MedChem Express

Telmisartan(BIBR 277) is an angiotensin II receptor antagonist (angiotensin receptor blocker, ARB) used in the management of hypertension.; IC50 Value: 9.2 nM [1]; Target: Angiotensin Receptor; in vitro: In intact RVSMC cells and in membrane preparations, telmisartan inhibits the binding of 125I-AngII to AT1 receptors in a concentrationdependent manner, with an IC50 of 9.2 ?0.8 nM. MedChem Express HY-13955

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density:	1.2±0.1 g/cm³
Boiling Point:	771.9±70.0 °C at 760 mmHg
Vapour Pressure:	0.0±2.8 mmHg at 25°C
Enthalpy of Vaporization:	117.9±3.0 kJ/mol
Flash Point:	420.6±35.7 °C
Index of Refraction:	1.667
Molar Refractivity:	154.5±0.5 cm³
#H bond acceptors:	6
#H bond donors:	1
#Freely Rotating Bonds:	7
#Rule of 5 Violations:	2

ACD/LogP:	7.73
ACD/LogD (pH 5.5):	5.19
ACD/BCF (pH 5.5):	1899.12
ACD/KOC (pH 5.5):	2364.03
ACD/LogD (pH 7.4):	4.01
ACD/BCF (pH 7.4):	125.93
ACD/KOC (pH 7.4):	156.75
Polar Surface Area:	73 Å²
Polarizability:	61.3±0.5 10^-24cm³
Surface Tension:	48.7±7.0 dyne/cm
Molar Volume:	414.9±7.0 cm³

Click to predict properties on the Chemicalize site

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Telmisartan

More details:

Experimental Melting Point:

Experimental Solubility:

Safety:

Target Organs:

Chemical Class:

Bio Activity:

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