ChemSpider 2D Image | Prazosin | C19H22ClN5O4

Prazosin

  • Molecular FormulaC19H22ClN5O4
  • Average mass419.862 Da
  • Monoisotopic mass419.136017 Da
  • ChemSpider ID61820

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

[4-(4-Amino-6,7-dimethoxy-2-chinazolinyl)-1-piperazinyl](2-furyl)methanonhydrochlorid (1:1) [German] [ACD/IUPAC Name]
[4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone hydrochloride
[4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone hydrochloride (1:1) [ACD/IUPAC Name]
[4-(4-Amino-6,7-diméthoxy-2-quinazolinyl)-1-pipérazinyl](2-furyl)méthanone, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
[4-(4-Amino-6,7-dimethoxychinazolin-2-yl)piperazin-1-yl](furan-2-yl)methanonhydrochlorid
[4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](2-furyl)methanone hydrochloride (1:1)
[4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](furan-2-yl)methanone hydrochloride
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride
19237-84-4 [RN]
2-[4-(furan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine hydrochloride
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

X0Z7454B90 [DBID]
D00609 [DBID]
EU-0101002 [DBID]
MLS000028454 [DBID]
NSC 292810 [DBID]
P7791_SIGMA [DBID]
SMR000058384 [DBID]
UNII:X0Z7454B90 [DBID]
UNII-X0Z7454B90 [DBID]
  • Experimental Physico-chemical Properties
  • Predicted Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      Potassium channel inhibitor;ABC inhibitor;Adrenergic Receptor antagonist ;MRP inhibitor TargetMol T1050

    • Bio Activity:

      &alpha;<sub>1</sub> and &alpha;<sub>2</sub> adrenoceptor antagonist Hello Bio HB2767
      &alpha;<sub>1</sub> and &alpha;<sub>2</sub> adrenoceptor antagonist (K<sub>i</sub> values are 0.32, 0.19 and 0.27 nM respectively). Also shows selective activity at MT<sub>3</sub> melatonin receptor. Shows variety of biological actions. Hello Bio HB2767
      ?1 and ?2B antagonist. MT3 antagonist Tocris Bioscience 0623, 623
      ?1 and ?2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM). Also available as part of the ?1-Adrenoceptor Tocriset? and Mixed Adrenergic Tocriset?. Tocris Bioscience 623
      ?1 and ?2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM). Also available as part of the ?1-Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™. Tocris Bioscience 0623
      7-TM Receptors Tocris Bioscience 623
      Adrenergic Alpha-1 Receptors Tocris Bioscience 623
      Adrenergic Receptor MedChem Express HY-B0193A
      Adrenergic Receptors Tocris Bioscience 623
      alpha1 and alpha2B antagonist. MT3 antagonist Tocris Bioscience 623
      alpha1 and alpha2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM). Also available as part of the alpha1-Adrenoceptor Tocriset? and Mixed Adrenergic Tocriset?. Tocris Bioscience 623
      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio HB2767
      GPCR/G protein MedChem Express HY-B0193A
      GPCR/G Protein TargetMol T1050
      GPCR/G protein; MedChem Express HY-B0193A
      Potassium Channel ;ABCG;Adrenergic receptor ;MRP1 TargetMol T1050
      Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder. MedChem Express
      Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.; Target: Adrenergic Receptor; Prazosin, is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, andpanic disorder. MedChem Express HY-B0193A
      Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.;Target: Adrenergic ReceptorPrazosin, is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, andpanic disorder. It is an alpha-adrenergic blocker that is specific for the alpha-1 receptors. These receptors are found on vascular smooth muscle, where they are responsible for the vasoconstrictive action of norepinephrine. They are also found throughout the central nervous system. As of 2013, prazosin is off-patent in the US, and the FDA has approved at least one generic manufacturer.In addition to its alpha-blocking activity, prazosin is an antagonist of the MT3 receptor (which is not present in humans), with selectivity for this receptor over the MT1 and MT2 receptors.Prazosin is orally active and has a minimal effect on cardiac function due to its alpha-1 receptor selectivity. However, when prazosin is initially started, MedChem Express HY-B0193A
      Receptors & Transporters/G protein coupled receptors/Adrenoceptors/&alpha;/&alpha;<sub>1</sub> Hello Bio HB2767
      Receptors & Transporters/G protein coupled receptors/Adrenoceptors/&alpha;/Non-selective Hello Bio HB2767

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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