ChemSpider 2D Image | Ondansetron Hydrochloride | C18H20ClN3O

Ondansetron Hydrochloride

  • Molecular FormulaC18H20ClN3O
  • Average mass329.824 Da
  • Monoisotopic mass329.129486 Da
  • ChemSpider ID61903

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-, hydrochloride (1:1) [ACD/Index Name]
4H-carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-, monohydrochloride
99614-01-4 [RN]
9-méthyl-3-[(2-méthyl-1H-imidazol-1-yl)méthyl]-1,2,3,9-tétrahydro-4H-carbazol-4-one chlorhydrate
9-Methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride
9-Methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride (1:1) [ACD/IUPAC Name]
9-Méthyl-3-[(2-méthyl-1H-imidazol-1-yl)méthyl]-1,2,3,9-tétrahydro-4H-carbazol-4-one, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4h-carbazol-4-onhydrochlorid
9-Methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-onhydrochlorid (1:1) [German] [ACD/IUPAC Name]
MFCD00374371 [MDL number]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

2999F27MAD [DBID]
UNII:2999F27MAD [DBID]
FE6373975 [DBID]
FE6375500 [DBID]
GR 38032 [DBID]
GR 38032 | [DBID]
GR 38032X [DBID]
GR-38032F [DBID]
NSC 665799 [DBID]
NSC665799 [DBID]
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  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      25-41-50/53 LKT Labs [O5212]
      Danger Biosynth Q-201515
      GHS06 Biosynth Q-201515
      H301 Biosynth Q-201515
      H301 H318 H410 LKT Labs [O5212]
      P301+P310 Biosynth Q-201515
      T LKT Labs [O5212]
      UN 2811 LKT Labs [O5212]
    • Bio Activity:

      5-HT Receptor MedChem Express HY-B0002
      5-HT3 Receptors Tocris Bioscience 2891
      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio [HB2832]
      GPCR/G protein MedChem Express HY-B0002
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-B0002
      Ion Channels Tocris Bioscience 2891
      Ion channels/Ligand-gated ion channel/5-HT<sub>3</sub>/INACTIVE 5-HT<sub>3</sub> Hello Bio [HB2832]
      Ligand-gated Ion Channels Tocris Bioscience 2891
      Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy. MedChem Express
      Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.; Target: 5- HT Receptor; IC50 Value: ; in vitro: 5-HT evoked transient inward currents (EC50 = 3.4 microM; Hill coefficient = 1.8) that were blocked by the 5-HT3 receptor antagonist ondansetron (IC50 = 103 pM) [1]. MedChem Express HY-B0002
      Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.;Target: 5- HT Receptor;IC50 Value: ;In vitro: 5-HT evoked transient inward currents (EC50 = 3.4 microM; Hill coefficient = 1.8) that were blocked by the 5-HT3 receptor antagonist ondansetron (IC50 = 103 pM) [1]. The 5-HT3A receptor antagonist ondansetron (0.3 nM) reversibly inhibited the 5-HT (30 microM) signal by 70% and at 3 nM it abolished the response [2].;In vivo: Acute ondansetron administration at the lowest dose (0.1 mg/kg, IP) tested had no effect, while other doses (0.33 and 1 mg/kg, IP) produced improvements in auditory gating [3]. Different doses of ondansetron were injected intraperitoneally (i.p.) at fixed times during the day to determine both the sublethal (TD50) and lethal (LD50) doses, which were, respectively, 3.7 +/- 0.6 mg/kg and 4.6 +/- 0.5 mg/kg [4]. ondansetron (0.25-1.0 mg/kg, subcutaneously) given before the challe MedChem Express HY-B0002
      Potent, selective 5-HT<sub>3</sub> antagonist Hello Bio [HB2832]
      Potent, selective 5-HT<sub>3</sub> antagonist. Shows anti-emetic actions. Active <em>in vivo</em>. Hello Bio [HB2832]
      Selective 5-HT3 antagonist Tocris Bioscience 2891
      Selective 5-HT3 receptor antagonist (Ki = 6.16 nM). Antiemetic; prevents emesis induced by cytotoxic drugs and radiation. Tocris Bioscience 2891

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

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