ChemSpider 2D Image | Loperamide hydrochloride | C29H34Cl2N2O2

Loperamide hydrochloride

  • Molecular FormulaC29H34Cl2N2O2
  • Average mass513.498 Da
  • Monoisotopic mass512.199707 Da
  • ChemSpider ID64510

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Loperamide hydrochloride [JAN] [USAN]
1-piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-, hydrochloride (1:1)
1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, hydrochloride (1:1) [ACD/Index Name]
252-082-4 [EINECS]
34552-83-5 [RN]
4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide hydrochloride
4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-N,N-dimethyl-2,2-diphenylbutanamide hydrochloride
4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-N,N-dimethyl-2,2-diphenylbutanamide hydrochloride (1:1) [ACD/IUPAC Name]
4-[4-(4-Chlorophényl)-4-hydroxy-1-pipéridinyl]-N,N-diméthyl-2,2-diphénylbutanamide, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
4-[4-(4-chlorophényl)-4-hydroxypipéridin-1-yl]-N,N-diméthyl-2,2-diphénylbutanamide chlorhydrate
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

PJ 185 [DBID]
34014_RIEDEL [DBID]
D00729 [DBID]
EU-0100708 [DBID]
L4762_SIGMA [DBID]
MLS000069779 [DBID]
NSC696356 [DBID]
Prestwick_302 [DBID]
R 18553 [DBID]
SMR000058466 [DBID]
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  • Experimental Physico-chemical Properties
  • Predicted Physico-chemical Properties
  • Miscellaneous
    • Appearance:

      WHITE POWDER NIH Clinical Collection [SMR000058466]
    • Safety:

      25 LKT Labs [L5660]
      Danger Biosynth W-106729
      GHS06 Biosynth W-106729
      H301 Biosynth W-106729
      H301 LKT Labs [L5660]
      P301+P310 Biosynth W-106729
      T LKT Labs [L5660]
      UN Number: 2811 Class: 6.1 Packing Group: 3Proper shipping name: Toxic solids, organic, n.o.s. (4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-?,?-diphenylpiperidine-1- butyramide monohydr ochloride) Marine pollutant: No Poison Inhalation Hazard: No LKT Labs [L5660]
    • Target Organs:

      Calcium Channel;Calmodulin inhibitor;Opioid Receptor agonist TargetMol T0209
    • Chemical Class:

      A hydrochloride obtained by combining loperamide with one equivalent of hydrochloric acid. Used for treatment of diarrhoea resulting from gastroenteritis or inflammatory bowel disease. ChEBI CHEBI:6533, https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:6533
    • Drug Status:

      USP, INN, BAN, JAN Microsource [02300241]
    • Compound Source:

      synthetic Microsource [02300241]
    • Bio Activity:

      7-TM Receptors Tocris Bioscience 840
      Biochemicals & small molecules/Agonists & activators Hello Bio [HB0385]
      Calcium Channel;Calmodulin;Opioid receptor;Pro-opiomelanocortin TargetMol T0209
      GPCR/G protein MedChem Express HY-B0418A
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-B0418A
      High affinity ?-opioid receptor agonist with peripheral selectivity (Ki values are 2, 48 and 1156 nM for ?-, ?- and ?-opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca2+ channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca2+ channels and at higher concentrations it reduces Ca2+ flux through NMDA receptor operated channels. Tocris Bioscience 0840
      High affinity ?-opioid receptor agonist with peripheral selectivity (Ki values are 2, 48 and 1156 nM for ?-, ?- and ?-opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca2+ channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca2+ channels and at higher concentrations it reduces Ca2+ flux through NMDA receptor operated channels. Tocris Bioscience 840
      High affinity mu-opioid receptor agonist with peripheral selectivity (Ki values are 2, 48 and 1156 nM for mu-, delta- and kappa-opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca2+ channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca2+ channels and at higher concentrations it reduces Ca2+ flux through NMDA receptor operated channels. Tocris Bioscience 840
      Loperamide HCl is an opioid-receptor agonist used as long-acting synthetic antidiarrheals. MedChem Express
      Loperamide HCl is an opioid-receptor agonist used as long-acting synthetic antidiarrheals.; Target: Opioid Receptor; Loperamide is an effective therapy for a variety of diarrheal syndromes. MedChem Express HY-B0418A
      Membrane Transporter/Ion Channel; Neuroscience TargetMol T0209
      Mu Opioid Receptors Tocris Bioscience 840
      Opioid Receptor MedChem Express HY-B0418A
      Opioid Receptors Tocris Bioscience 840
      Peripherally acting ? agonist; Ca2+ channel blocker Tocris Bioscience 0840, 840
      Peripherally acting mu agonist; Ca2+ channel blocker Tocris Bioscience 840
      Potent and selective &micro;-opioid receptor agonist (K<sub>i</sub> values are 3, 48 and 1156 nM for &micro;, &delta; and &kappa;). Blocks voltage-activated calcium channels and also NMDA receptor Ca<sup>2+</sup> influx at higher concentrations. Shows antidiarrheal and antihyperalgesic actions. Hello Bio [HB0385]
      Potent, selective &micro;-opioid receptor agonist Hello Bio [HB0385]
      Receptors & Transporters/G protein coupled receptors/Opioid Hello Bio [HB0385]

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site






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