ChemSpider 2D Image | Rizatriptan benzoate | C22H25N5O2

Rizatriptan benzoate

  • Molecular FormulaC22H25N5O2
  • Average mass391.466 Da
  • Monoisotopic mass391.200836 Da
  • ChemSpider ID70382

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

145202-66-0 [RN]
1H-Indole-3-ethanamine, N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-, benzoate (1:1) [ACD/Index Name]
benzoic acid; dimethyl(2-{5-[(1H-1,2,4-triazol-1-yl)methyl]-1H-indol-3-yl}ethyl)amine
Benzolcarbonsäure--N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamin(1:1)
Maxalt [Trade name]
MFCD00866224 [MDL number]
N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine benzoate salt
N,N-Dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanaminbenzoat (1:1) [German] [ACD/IUPAC Name]
N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine benzoate
N,N-diméthyl-2-[5-(1H-1,2,4-triazol-1-ylméthyl)-1H-indol-3-yl]éthanamine benzoate
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

MK-462 [DBID]
D00675 [DBID]
L 705126 [DBID]
L-705126 [DBID]
LS-173238 [DBID]
MK 0462 [DBID]
MK 462 [DBID]
MK-0462 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      5-HT Receptor antagonist TargetMol T1512

    • Therapeutical Effect:

      5HT-1B/1D agonist, antimigraine Rudolf Boehm Institute [01505189]

    • Compound Source:

      synthetic; MK-0462 (benzoate) Rudolf Boehm Institute [01505189]

    • Bio Activity:

      5-HT Receptor MedChem Express HY-B0206
      5-HT Receptor TargetMol T1512
      5-HT Receptors Tocris Bioscience 5136
      5-HT1 Receptors Tocris Bioscience 5136
      5-HT1B/1D agonist. Antimigraine agent; attenuates effects of CGRP on light aversion in mice. Orally bioavailable. Tocris Bioscience 5136
      7-TM Receptors Tocris Bioscience 5136
      GPCR/G protein MedChem Express HY-B0206
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-B0206
      Neuroscience TargetMol T1512
      Potent 5-HT1B/1D agonist Tocris Bioscience 5136
      Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches. MedChem Express
      Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches.; Target: 5-HT1 agonist ; Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches. MedChem Express HY-B0206
      Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches.;Target: 5-HT1 agonist Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches. It is believed to work by narrowing the blood vessels around the brain. Rizatriptan also reduces the substances in the body, which can also reduce headache pain, nausea, sensitivity to light and sound and other migraine symptoms.Rizatriptan was rapidly absorbed with a median tmax of 1.3 h (range 1-3 h) vs a tmax for sumatriptan of 2.5 h (range 1-4 h, P < 0.001). Administration of either rizatriptan or sumatriptan produced maximal mean elevations of 5-10 mmHg in systolic and diastolic blood pressures without effect on heart rate; the changes occurred sooner following rizatriptan, consistent with more rapid absorption. Both rizatriptan and sumatriptan provoked mild increases in serum growth hormone without any effect on serum prolactin concentrations. The most MedChem Express HY-B0206

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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