ChemSpider 2D Image | Anamorelin | C31H42N6O3

Anamorelin

  • Molecular FormulaC31H42N6O3
  • Average mass546.704 Da
  • Monoisotopic mass546.331848 Da
  • ChemSpider ID8004650
  • defined stereocentres - 2 of 2 defined stereocentres


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

249921-19-5 [RN]
3-{(2R)-3-{(3R)-3-Benzyl-3-[(trimethylhydrazino)carbonyl]-1-piperidinyl}-2-[(2-methylalanyl)amino]-3-oxopropyl}-1H-indol [German] [ACD/IUPAC Name]
3-{(2R)-3-{(3R)-3-Benzyl-3-[(trimethylhydrazino)carbonyl]-1-piperidinyl}-2-[(2-methylalanyl)amino]-3-oxopropyl}-1H-indole [ACD/IUPAC Name]
3-{(2R)-3-{(3R)-3-Benzyl-3-[(triméthylhydrazino)carbonyl]-1-pipéridinyl}-2-[(2-méthylalanyl)amino]-3-oxopropyl}-1H-indole [French] [ACD/IUPAC Name]
3-Piperidinecarboxylic acid, 1-[(2R)-2-[(2-amino-2-methyl-1-oxopropyl)amino]-3-(1H-indol-3-yl)-1-oxopropyl]-3-(phenylmethyl)-, 1,2,2-trimethylhydrazide, (3R)- [ACD/Index Name]
8846
Anamorelin [INN] [Wiki]
anamorelina [Spanish] [INN]
anamoréline [French] [INN]
anamorelinum [Latin] [INN]
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      Anamorelin(RC1291; ONO-7643) is a synthetic orally active ghrelin receptor agonist which is under development for the management of non-small lung cancer associated cachexia/anorexia. MedChem Express http://www.medchemexpress.com/VE-821.html, HY-14734
      Anamorelin(RC1291; ONO-7643) is a synthetic orally active ghrelin receptor agonist which is under development for the management of non-small lung cancer associated cachexia/anorexia. ;IC50 Value:;Target: GHSRAnamorelin hydrochloride is the orally bioavailable hydrochloride salt of a synthetic, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play a direct role in cancer-related loss of appetite. MedChem Express HY-14734
      GHSR MedChem Express HY-14734
      GPCR/G protein MedChem Express HY-14734
      GPCR/G protein; MedChem Express HY-14734

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.2±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.619
Molar Refractivity: 157.8±0.3 cm3
#H bond acceptors: 9
#H bond donors: 4
#Freely Rotating Bonds: 9
#Rule of 5 Violations: 1
ACD/LogP: 2.98
ACD/LogD (pH 5.5): 0.66
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 5.77
ACD/LogD (pH 7.4): 2.34
ACD/BCF (pH 7.4): 27.29
ACD/KOC (pH 7.4): 274.60
Polar Surface Area: 115 Å2
Polarizability: 62.6±0.5 10-24cm3
Surface Tension: 57.4±3.0 dyne/cm
Molar Volume: 450.0±3.0 cm3

Click to predict properties on the Chemicalize site






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