ChemSpider 2D Image | Varenicline tartrate | C17H19N3O6

Varenicline tartrate

  • Molecular FormulaC17H19N3O6
  • Average mass361.349 Da
  • Monoisotopic mass361.127380 Da
  • ChemSpider ID8082594

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(2R,3R)-2,3-Dihydroxybernsteinsäure --5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4(9),5,7,10-pentaen (1:1) [German] [ACD/IUPAC Name]
(2R,3R)-2,3-Dihydroxysuccinic acid - 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4(9),5,7,10-pentaene (1:1) [ACD/IUPAC Name]
,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-
375815-87-5 [RN]
Acide (2R,3R)-2,3-dihydroxysuccinique - 5,8,14-triazatétracyclo[10.3.1.02,11.04,9]hexadéca-2,4(9),5,7,10-pentaène (1:1) [French] [ACD/IUPAC Name]
Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with 7,8,9,10-tetrahydro-6,10-methano-6H-azepino[4,5-g]quinoxaline (1:1) [ACD/Index Name]
Varenicline (tartrate)
Varenicline tartrate [USAN]
7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine (2R,3R)-2,3-dihydroxybutanedioate
7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine (2R,3R)-2,3- dihydroxybutanedioate
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CP-526,555-18 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      A tartrate salt obtained by reaction of varenicline with one equivalent of (<stereo>R</stereo>,<stereo>R</stereo>)-tartaric acid. A partial agonist for nicotinic cholinergic receptors, it is used as a n aid to giving up smoking. ChEBI CHEBI:84507
      A tartrate salt obtained by reaction of varenicline with one equivalent of (R,R)-tartaric acid. A partial agonist for nicotinic cholinergic receptors, it is used as an aid to giving up smoking. ChEBI CHEBI:84507

    • Bio Activity:

      <p>Subtype-selective ?4?2 nicotinic receptor partial agonist (K<sub>i</sub> values are 0.06, 240, 322 and 3540 nM for ?4?2, ?3?4, ?7, ?1??? receptors respectively). </p> <p>Also activates PSAM<sup>4</sup>-5HT3 and PSAM<sup>4</sup>-GlyR (EC<sub>50</sub> values are 4 nM and 1.6 nM respectively) chimeric ion channels to silence neurons. <p>Stimulates dopamine release. Orally active. Shows excellent brain penetrance.</p> Hello Bio HB2070
      Membrane Tranporter/Ion Channel MedChem Express HY-10021
      Membrane Tranporter/Ion Channel; Neuronal Signaling; MedChem Express HY-10021
      nAChR MedChem Express HY-10021
      Varenicline Tartrate(CP 526555;Champix) is a nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.; IC50 value:; Target: ?4?2 nAChR; Varenicline(CP 526555; Champix; Chantix) is a prescription medication used to treat smoking addiction. MedChem Express HY-10021

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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