ChemSpider 2D Image | Lurasidone Hydrochloride | C28H37ClN4O2S

Lurasidone Hydrochloride

  • Molecular FormulaC28H37ClN4O2S
  • Average mass529.137 Da
  • Monoisotopic mass528.232544 Da
  • ChemSpider ID9412905

  • defined stereocentres - 6 of 6 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

((3aR,4S,7R,7aS)-2-{(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-ylmethyl]cyclohexylmethyl}hexahydro-4,7-methano-2H-isoindole-1,3-dione hydrochloride
(1R,2S,6R,7S)-4-{[(1R,2R)-2-{[4-(1,2-Benzothiazol-3-yl)-1-piperazinyl]methyl}cyclohexyl]methyl}-4-azatricyclo[5.2.1.02,6]decan-3,5-dionhydrochlorid (1:1) [German] [ACD/IUPAC Name]
(1R,2S,6R,7S)-4-{[(1R,2R)-2-{[4-(1,2-Benzothiazol-3-yl)-1-piperazinyl]methyl}cyclohexyl]methyl}-4-azatricyclo[5.2.1.02,6]decane-3,5-dione hydrochloride (1:1) [ACD/IUPAC Name]
(1R,2S,6R,7S)-4-{[(1R,2R)-2-{[4-(1,2-Benzothiazol-3-yl)-1-pipérazinyl]méthyl}cyclohexyl]méthyl}-4-azatricyclo[5.2.1.02,6]décane-3,5-dione, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
200-659-6 [EINECS]
367514-88-3 [RN]
4,7-Methano-1H-isoindole-1,3(2H)-dione, 2-[[(1R,2R)-2-[[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-, (3aR,4S,7R,7aS)-, hydrochloride (1:1) [ACD/Index Name]
Latuda [Trade name]
Lurasidone HCl
Lurasidone Hydrochloride [INN] [USAN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

SM-13496 [DBID]
SM 13496 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      A hydrochloride obtained by reaction of lurasidone with one equivalent of hydrochloric acid. An atypical antipsychotic agent used for the treatment of schizophrenia. ChEBI CHEBI:70732

    • Bio Activity:

      5-HT Receptor MedChem Express HY-B0032
      5-HT Receptor Dopamine Receptor MedChem Express HY-B0032
      GPCR/G protein MedChem Express HY-B0032
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-B0032
      Lurasidone Hcl (SM 13496 Hcl) is an inhibitor of Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline ?2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively.; IC50 Value: 1.68 nM(Dopamine D2); 2.03 nM(5-HT2A); 0.495 nM(5-HT7); 6.75 nM(5-HT1A); 10.8 nM (noradrenaline ?2C); Target: 5-HT Receptor; Dopamine Receptor; in vitro: Lurasidone antagonizes dopamine-stimulated [35S]GTP?S binding at human dopamine D2L receptor in a concentration-dependent manner with a KB value of 2.8 nM. MedChem Express HY-B0032

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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