ChemSpider 2D Image | AMN082 | C28H30Cl2N2

AMN082

  • Molecular FormulaC28H30Cl2N2
  • Average mass465.457 Da
  • Monoisotopic mass464.178589 Da
  • ChemSpider ID9873115

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1,2-Ethanediamine, N1,N2-bis(diphenylmethyl)-, hydrochloride (1:2) [ACD/Index Name]
97075-46-2 [RN]
AMN082
MFCD08702723
N,N'-Bis(diphenylmethyl)-1,2-ethandiamindihydrochlorid [German] [ACD/IUPAC Name]
N,N'-Bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride [ACD/IUPAC Name]
N,N'-Bis(diphénylméthyl)-1,2-éthanediamine, dichlorhydrate [French] [ACD/IUPAC Name]
N,N'-Bis(diphenylmethyl)ethane-1,2-diamine dihydrochloride
N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride
(DIPHENYLMETHYL)({2-[(DIPHENYLMETHYL)AMINO]ETHYL})AMINE DIHYDROCHLORIDE
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

A6605_SIGMA [DBID]
  • References
  • Experimental Physico-chemical Properties
    • Experimental Solubility:

      Soluble to 100 mM in DMSO and to 10 mM in methanol Tocris Bioscience 2385
      Soluble to 100 mM in DMSO and to 2 mM in water with gentle warming Tocris Bioscience 2385
      Soluble to 100 mM in DMSO and to 5 mM in water with gentle warming Tocris Bioscience 2385
  • Miscellaneous
    • Bio Activity:

      <p>AMN 082 dihydrochloride is a selective mGlu<sub>7</sub> positive allosteric agonist. It is orally active and blood-brain barrier permeable.</p> <p><br />AMN 082 binds at the mGlu<sub>7</sub> allosteric site and at &le;10 &mu;M fails to show appreciable activating or inhibitory effects at other mGluR subtypes and selected iGluRs.</p> <p><br /><span style=text-decoration: underline;><strong>Uses</strong></span></p> <p>AMN 082 effects may differ depending on brain region. For example, AMN082 decreases GABA and increases glutamate levels in the nucleus accumbens and amygdala and decreases glutamate and GABA release in the periaqueductal gray (PAG).</p> <p><br />It potently inhibits accumulation of cAMP and stimulates GTP&gamma;S binding (EC<sub>50</sub> = 64 - 290 nM) with agonist efficacies comparable with those of <a href=/lap4.html title=L-AP4 | Hello Bio target=_self>L-AP4</a>. AMN082 also increase splasma corticosterone and ACTH levels.</p> <p><br />AMN082 reduces fear acquisition and LTP in the amygdala but improves fear extinction. AMN 082 also produces anxiogenic- and anxiolytic-like effects, can facilitate nociception, shows anti-depressant-like activity, reduces ethanol and cocaine intake and facilitates extinction of aversive memories.</p> Hello Bio HB0113
      7-TM Receptors Tocris Bioscience 2385
      Biochemicals & small molecules/Agonists & activators Hello Bio HB0113
      Glutamate (Metabotropic) Group III Receptors Tocris Bioscience 2385
      Glutamate (Metabotropic) Receptors Tocris Bioscience 2385
      Receptors & Transporters/G protein coupled receptors/Metabotropic glutamate/Group III (mGlu<sub>4</sub>, mGlu<sub>6</sub>, mGlu<sub>7</sub>, mGlu<sub>8</sub>) Hello Bio HB0113
      Selective mGlu<sub>7</sub> agonist Hello Bio HB0113
      The first selective mGlu7 agonist Tocris Bioscience 2385
      The first selective mGlu7 agonist. Potently inhibits cAMP accumulation and stimulates GTP?S binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Selective over other mG luR subtypes and selected ionotropic glutamate receptors up to 10 ?M. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats. Tocris Bioscience 2385
      The first selective mGlu7 agonist. Potently inhibits cAMP accumulation and stimulates GTP?S binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 ?M. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats. Tocris Bioscience 2385
      The first selective mGlu7 agonist. Potently inhibits cAMP accumulation and stimulates GTPgammaS binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 muM. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats. View important information regarding the usage of AMN 082 dihydrochloride. Tocris Bioscience 2385

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site






Advertisement