ChemSpider 2D Image | AV-412 | C41H44ClFN6O7S2

AV-412

  • Molecular FormulaC41H44ClFN6O7S2
  • Average mass851.406 Da
  • Monoisotopic mass850.238525 Da
  • ChemSpider ID9875421

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-methylbenzenesulfonate (1:2) [ACD/Index Name]
451493-31-5 [RN]
4-Methylbenzolsulfonsäure --N-{4-[(3-chlor-4-fluorphenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butin-1-yl]-6-chinazolinyl}acrylamid (2:1) [German] [ACD/IUPAC Name]
Acide 4-méthylbenzènesulfonique - N-{4-[(3-chloro-4-fluorophényl)amino]-7-[3-méthyl-3-(4-méthyl-1-pipérazinyl)-1-butyn-1-yl]-6-quinazolinyl}acrylamide (2:1) [French] [ACD/IUPAC Name]
AV-412
BIS(4-METHYLBENZENE-1-SULFONIC ACID); N-{4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-7-[3-METHYL-3-(4-METHYLPIPERAZIN-1-YL)BUT-1-YN-1-YL]QUINAZOLIN-6-YL}PROP-2-ENAMIDE
N-{4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl}acrylamide 4-methylbenzenesulfonate (1:2) [ACD/IUPAC Name]
[451493-31-5] [RN]
2-Propenamide,N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-,4-Methylbenzenesulfonate(1:2)
2-PROPENAMIDE-N-[4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-7-[3-METHYL-3-(4-METHYL-1-PIPERAZINYL)-1-BUTYN-1-YL]-6-QUINAZOLINYL]-4-METHYLBENZENESULFONATE
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Z541VW0W40 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      AV-412(MP-412, 2 tosylate salt) is a potent dual inhibitor of EGFR and ErbB2(IC50=19 nM) tyrosine kinases, including the mutant EGFR(L858R IC50=0.51 nM, T790M IC50=0.79 nM); inhibits autophosphorylati on of EGFR and ErbB2 with IC(50) of 43 and 282 nM, respectively. MedChem Express
      AV-412(MP-412, 2 tosylate salt) is a potent dual inhibitor of EGFR and ErbB2(IC50=19 nM) tyrosine kinases, including the mutant EGFR(L858R IC50=0.51 nM, T790M IC50=0.79 nM); inhibits autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM, respectively.;IC50 value: 0.51 nM (EGFR L858R); 0.79 nM (EGFRT790M); 19 nM (ErbB2) [1];Target: EGFR; ErbB2; Mutant EGFR L858R/T790M;In vitro: MP-412 (AV-412) is a potent dual inhibitor of EGFR and ErbB2 tyrosine kinases, including the mutant EGFR(L858R,T790M), which is clinically resistant to the EGFR-specific kinase inhibitors erlotinib and gefitinib. In an enzyme assay, MP-412 inhibited the EGFR variants and ErbB2 in the nanomolar range with over 100-fold selectivity compared with other kinases, apart from abl and flt-1, which were both moderately sensitive to the compound. In cells, MP-412 inhibited autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM, respectively. It also inhibited epidermal growth factor (EGF)-depen MedChem Express HY-10346
      EGFR MedChem Express HY-10346
      JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; MedChem Express HY-10346

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


Advertisement