StreptomeDB is a database that stores information of natural compounds produced by bacteria of the genus Streptomyces. These metabolites are very important for the production of natural drugs such as antibiotic, antitumor or immunosuppressant drugs. In addition to the structures of the compounds, we have included information about source organisms, references, biological role, activities, and syntheses-routes (e.g. polyketide synthase (PKS)-derived, non-ribosomal peptides (NRPs)-derived).