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Search term: GHOSNRCGJFBJIB-UHFFFAOYSA-N (Found by InChIKey (full match))

Candesartan cilexetil

Molecular FormulaC₃₃H₃₄N₆O₆
Average mass610.660 Da
Monoisotopic mass610.253967 Da
ChemSpider ID2444

More details:

Names and Synonyms
Database ID(s)

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-{[(Cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylate [ACD/IUPAC Name]

1-{[(Cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(2H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylate

1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

1-{[(Cyclohexyloxy)carbonyl]oxy}ethyl-2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-benzimidazol-7-carboxylat [German] [ACD/IUPAC Name]

1-{[(Cyclohexyloxy)carbonyl]oxy}ethyl-2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazol-7-carboxylat [German]

145040-37-5 [RN]

1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester [ACD/Index Name]

2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl Ester

2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-Benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester

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2-Éthoxy-1-{[2'-(1H-tétrazol-5-yl)-4-biphénylyl]méthyl}-1H-benzimidazole-7-carboxylate de 1-{[(cyclohexyloxy)carbonyl]oxy}éthyle [French] [ACD/IUPAC Name]

2-éthoxy-1-{[2'-(1H-tétrazol-5-yl)biphényl-4-yl]méthyl}-1H-benzimidazole-7-carboxylate de 1-{[(cyclohexyloxy)carbonyl]oxy}éthyle [French]

Candesartan cilexetil [JAN] [USAN]

MFCD00871371 [MDL number]

TCY 116

(±)-1-Hydroxyethyl 2-Ethoxy-1-[p-(o-1H-tetrazol-5-ylphenyl)l]-7-benzimidazolecarboxylate Cyclohexyl Carbonate (Ester)

(2-ethoxy-1-{[4-(2-(1H-1,2,3,4-tetraazol-5-yl)phenyl)phenyl]methyl}benzimidazol-7-ylcarbonyloxy)ethyl cyclohexyloxyformate

[145040-37-5] [RN]

1-(((cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethox

1-(((cyclohexyloxy)carbonyl)oxy)ethyl 1-((2-(2h-tetrazol-5-yl)-[1,1-biphenyl]-4-yl)methyl)-2-ethoxy-1h-benzo[d]imidazole-7-carboxylate

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

1-(cyclohexoxycarbonyloxy)ethyl 2-ethoxy-3-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate

1-(cyclohexylocarbonyloxy)ethyl-2-ethoxy-1-(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)-1H-benzimidazole-7-carboxylate

1-(cyclohexyloxycarbonyloxy)ethyl 1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate

1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-(ethyloxy)-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-1,3-benzodiazole-7-carboxylate

1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylate

1261393-19-4 [RN]

1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate

1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate

1H-Benzimidazolium, 7-carboxy-1-(2-((cyclohexylcarbonyl)oxy)ethyl)-2-ethoxy-1-(2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)-, hydroxide, inner salt, (±)-

2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester-1H-Benzimidazole-7-carboxylic acid

2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester

2-Ethoxy-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylic acid [ACD/IUPAC Name]

2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid 1-cyclohexyloxycarbonyloxy-ethyl ester

2-Ethoxy-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid 1-cyclohexyloxycarbonyloxy-ethyl ester

7689-03-4 [RN]

Amias [Trade name]

Atacand [Trade name]

Atacand (TN)

Blopress [Trade name]

Camptothecine

Candesartan 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester

Candesartan celexetil

Candesartan cilexetil (JP17/USP)

candesartan cilexetil(标准品) [Chinese]

candesartan cilexetil-d11

CANDESARTAN CILEXITIL

Kenzen

KS-1147

Parapres

Racanda

Ratacand [Trade name]

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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

R85M2X0D68 [DBID]

TCV 116 [DBID]

UNII:R85M2X0D68 [DBID]

BR-75900 [DBID]

C07709 [DBID]

CCRIS 937 [DBID]

D00626 [DBID]

DD6672500 [DBID]

KBio2_002187 [DBID]

KBio2_004755 [DBID]

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Experimental data
Predicted - ACD/Labs
Predicted - ChemAxon
Predicted - Mcule

Experimental Physico-chemical Properties

Experimental Solubility:

Miscellaneous

Target Organs:

RAAS antagonist;ACE inhibitor TargetMol T2400

Bio Activity:

7-TM Receptors Tocris Bioscience 4792

Ang II receptor TargetMol T2400

Angiogenesis;Endocrinology/ Hormones TargetMol T2400

Angiotensin Receptor MedChem Express HY-17505

Angiotensin Receptors Tocris Bioscience 4792

Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. MedChem Express

Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.; Target: Type-1 angiotensin II receptor; Candesartan is generally well tolerated and significantly reduced cardiovascular deaths and hospital admissions for heart failure. MedChem Express HY-17505

Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.;Target: Type-1 angiotensin II receptorCandesartan is generally well tolerated and significantly reduced cardiovascular deaths and hospital admissions for heart failure. Ejection fraction or treatment at baseline did not alter these effects [1]. In rats, TCV-116 inhibited the pressor responses to Ang I, Ang II, and Ang III without an effect on the bradykinin (BK)-induced depressor response. In SHR, the antihypertensive effect of TCV-116 (10 mg/kg) was larger than the maximum antihypertensive effect of enalapril and was not intensified by combination with enalapril. TCV-116 is more effective than enalapril in reducing blood pressure in SHR and 1K, 1C-HR, and that the BK- and/or prostaglandin-potentiating effect of enalapril contributes little to its antihypertensive mechanism in SHR [2]. MedChem Express HY-17505

GPCR/G protein MedChem Express HY-17505

GPCR/G protein; MedChem Express HY-17505

Peptide Receptors Tocris Bioscience 4792

Prodrug of candesartan (Cat. No. 4791), an AT1 receptor antagonist Tocris Bioscience 4792

Prodrug of the angiotensin II receptor 1 (AT1) antagonist candesartan (Cat. No. 4791), which exhibits antihypertensive effects in animal models. Tocris Bioscience 4792

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density:	1.4±0.1 g/cm³
Boiling Point:	843.3±75.0 °C at 760 mmHg
Vapour Pressure:	0.0±3.1 mmHg at 25°C
Enthalpy of Vaporization:	122.5±3.0 kJ/mol
Flash Point:	463.8±37.1 °C
Index of Refraction:	1.667
Molar Refractivity:	165.5±0.5 cm³
#H bond acceptors:	12
#H bond donors:	1
#Freely Rotating Bonds:	13
#Rule of 5 Violations:	3

ACD/LogP:	7.79
ACD/LogD (pH 5.5):	4.73
ACD/BCF (pH 5.5):	1137.99
ACD/KOC (pH 5.5):	2328.11
ACD/LogD (pH 7.4):	4.03
ACD/BCF (pH 7.4):	226.58
ACD/KOC (pH 7.4):	463.53
Polar Surface Area:	143 Å²
Polarizability:	65.6±0.5 10^-24cm³
Surface Tension:	54.0±7.0 dyne/cm
Molar Volume:	444.7±7.0 cm³

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Candesartan cilexetil

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