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Search term: HVRLZEKDTUEKQH-NOILCQHBSA-N (Found by InChIKey (full match))
ChemSpider 2D Image | Patanol | C21H24ClNO3

Patanol

  • Molecular FormulaC21H24ClNO3
  • Average mass373.873 Da
  • Monoisotopic mass373.144470 Da
  • ChemSpider ID4445557

  • Double-bond stereo - Double-bond stereo

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(11Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride
{(11Z)-11-[3-(Dimethylamino)propyliden]-6,11-dihydrodibenzo[b,e]oxepin-2-yl}essigsäurehydrochlorid
{(11Z)-11-[3-(Dimethylamino)propyliden]-6,11-dihydrodibenzo[b,e]oxepin-2-yl}essigsäurehydrochlorid (1:1) [German] [ACD/IUPAC Name]
{(11Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenzo[b,e]oxepin-2-yl}acetic acid hydrochloride
{(11Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenzo[b,e]oxepin-2-yl}acetic acid hydrochloride (1:1) [ACD/IUPAC Name]
140462-76-6 [RN]
2XG66W44KF
acide {(11Z)-11-[3-(diméthylamino)propylidène]-6,11-dihydrodibenzo[b,e]oxépin-2-yl}acétique chlorhydrate
Acide {(11Z)-11-[3-(diméthylamino)propylidène]-6,11-dihydrodibenzo[b,e]oxépin-2-yl}acétique, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
AL 4943A
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

KW-4679 [DBID]
D01192 [DBID]
KW 4679 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      Histamine Receptor TargetMol T1170

    • Bio Activity:

      7-TM Receptors Tocris Bioscience 4241
      GPCR/G protein MedChem Express HY-B0426A
      GPCR/G protein; MedChem Express HY-B0426A
      H1 antagonist; ocular antiallergic agent Tocris Bioscience 4241
      Histamine H1 receptor antagonist (Ki = 31.6 nM). Inhibits the release of histamine, prostaglandin D2 and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production. Tocris Bioscience 4241
      Histamine H1 receptor antagonist (Ki = 31.6 nM). Inhibits the release of histamine, prostaglandin D2 and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production. Tocris Bioscience 4241
      Histamine H1 Receptors Tocris Bioscience 4241
      Histamine Receptor MedChem Express HY-B0426A
      Histamine receptor TargetMol T1170
      Histamine Receptors Tocris Bioscience 4241
      Neuroscience TargetMol T1170
      Olopatadine HCl is a histamine blocker used to treat allergic conjunctivitis.; Target: Histamine Receptor; Olopatadine is one of the second-generation histamine H1 receptor antagonists that are treated for allergic disorders. MedChem Express HY-B0426A
      Olopatadine HCl is a histamine blocker used to treat allergic conjunctivitis.;Target: Histamine ReceptorOlopatadine is one of the second-generation histamine H1 receptor antagonists that are treated for allergic disorders. Olopatadine significantly inhibited the ear swelling and the increased production of IL-4, IL-1beta, IL-6, GM-CSF and NGF in the lesioned ear [1]. Olopatadine was highly and rapidly absorbed in healthy human volunteers. The urinary excretion of olopatadine accounted for not less than 58% and the contribution of metabolism was considerably low in the clearance of olopatadine in humans. Olopatadine is one of the few renal clearance drugs in antiallergic drugs. Olopatadine was shown to be useful for the treatment of allergic rhinitis and chronic urticaria in double-blind clinical trials [2]. AL-4943A inhibits histamine release in a concentration-dependent fashion (IC50 = 559 microM) from human conjunctival mast cell preparations in vitro. Passive anaphylaxis in guin MedChem Express HY-B0426A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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