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Search term: JVCWPUFNLFSKFS-UHFFFAOYSA-N (Found by InChIKey (full match))
ChemSpider 2D Image | AC710 | C31H42N6O4

AC710

  • Molecular FormulaC31H42N6O4
  • Average mass562.703 Da
  • Monoisotopic mass562.326782 Da
  • ChemSpider ID28646174

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1351522-04-7 [RN]
2-Pyridinecarboxamide, N-[4-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]- [ACD/Index Name]
5-[(1-Ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-N-[4-({[5-(2-methyl-2-propanyl)-1,2-oxazol-3-yl]carbamoyl}amino)phenyl]-2-pyridincarboxamid [German] [ACD/IUPAC Name]
5-[(1-Ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-N-[4-({[5-(2-methyl-2-propanyl)-1,2-oxazol-3-yl]carbamoyl}amino)phenyl]-2-pyridinecarboxamide [ACD/IUPAC Name]
5-[(1-Éthyl-2,2,6,6-tétraméthyl-4-pipéridinyl)oxy]-N-[4-({[5-(2-méthyl-2-propanyl)-1,2-oxazol-3-yl]carbamoyl}amino)phényl]-2-pyridinecarboxamide [French] [ACD/IUPAC Name]
AC710
AC-710
N-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}phenyl)-5-[(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridine-2-carboxamide
[1351522-04-7] [RN]
1351522-04-7 (free base)
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      AC710 is a potent, selective PDGFR-family kinases inhibitor with Kd values of 0.6 nM/1.0 nM/1.3 nM/1.0 nM for FLT3/KIT/PDGFR?/PDGFR? respectively.; IC50 value: 0.6 nM/1.0 nM/1.3 nM/1.0 nM (FLT3/KIT/PDGFR?/PDGFR?) [1]; Target: PGDFR inhibitor; AC710 demonstrated equivalent or slightly better efficacy in reducing the joint swelling and inflammation than dexomethasone administered at a safe dose. MedChem Express HY-13493
      Enzyme-Linked Receptors Tocris Bioscience 5013
      PDGFR Tocris Bioscience 5013
      PDGFR MedChem Express HY-13493
      Potent and selective PDGFR family inhibitor Tocris Bioscience 5013
      Potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFR? and CSF1R respectively; Kd = 1.3 nM for PDGFR?). Exhibits >30-fold selectivity over a panel of other kinase s and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthr itis. Orally active. Tocris Bioscience 5013
      Potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFR? and CSF1R respectively; Kd = 1.3 nM for PDGFR?). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active. Tocris Bioscience 5013
      Potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRbeta and CSF1R respectively; Kd = 1.3 nM for PDGFRalpha). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active. Tocris Bioscience 5013
      Protein Tyrosine Kinase/RTK MedChem Express HY-13493
      Protein Tyrosine Kinase/RTK; MedChem Express HY-13493
      Receptor Tyrosine Kinases (RTKs) Tocris Bioscience 5013

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.2±0.1 g/cm3
Boiling Point: 580.4±50.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.6 mmHg at 25°C
Enthalpy of Vaporization: 86.8±3.0 kJ/mol
Flash Point: 304.8±30.1 °C
Index of Refraction: 1.591
Molar Refractivity: 161.2±0.3 cm3
#H bond acceptors: 10
#H bond donors: 3
#Freely Rotating Bonds: 8
#Rule of 5 Violations: 2
ACD/LogP: 4.86
ACD/LogD (pH 5.5): 2.03
ACD/BCF (pH 5.5): 3.75
ACD/KOC (pH 5.5): 11.92
ACD/LogD (pH 7.4): 2.63
ACD/BCF (pH 7.4): 14.72
ACD/KOC (pH 7.4): 46.76
Polar Surface Area: 122 Å2
Polarizability: 63.9±0.5 10-24cm3
Surface Tension: 50.8±3.0 dyne/cm
Molar Volume: 476.6±3.0 cm3

Click to predict properties on the Chemicalize site


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