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Search term: MIDKPVLYXNLFGZ-UHFFFAOYSA-N (Found by InChIKey (full match))
ChemSpider 2D Image | BMS-345541 | C14H18ClN5

BMS-345541

  • Molecular FormulaC14H18ClN5
  • Average mass291.779 Da
  • Monoisotopic mass291.125061 Da
  • ChemSpider ID8101689

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1,2-Ethanediamine, N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)-, hydrochloride (1:1) [ACD/Index Name]
1,2-Ethanediamine, N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)-, hydrochloride (1:?)
445430-59-1 [RN]
547757-23-3 [RN]
BMS-345541 [Wiki]
bms-345541 free base hydrochloride
BXU277OCN5
MFCD07784499 [MDL number]
N-(1,8-Dimethylimidazo[1,2-a]chinoxalin-4-yl)-1,2-ethandiaminhydrochlorid (1:1) [German] [ACD/IUPAC Name]
N-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

B9935_SIGMA [DBID]
CCRIS 4693 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 ?M and 4 ?M, respectively.; IC50 value: 0.3/4 uM(IKK2/1) [1]; Target: IKK2/1; in vitro: BMS-345541 dose-dependently inhibits the TNF-?-stimulated phosphorylation of I?B? in THP-1 monocytic cells with an IC50 of ~4 ?M. MedChem Express HY-10518
      Enzymes Tocris Bioscience 4806
      IkB Kinase Tocris Bioscience 4806
      IKK MedChem Express HY-10518
      Kinases Tocris Bioscience 4806
      NF-KB MedChem Express HY-10518
      NF-KB; MedChem Express HY-10518
      Selective allosteric inhibitor of IKK (IC50 values are 0.3 and 4.0 ?M for IKK? and IKK? respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine productio n in vitro and blocks NF?B dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis. Tocris Bioscience 4806
      Selective allosteric inhibitor of IKK (IC50 values are 0.3 and 4.0 ?M for IKK? and IKK? respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production in vitro and blocks NF?B dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis. Tocris Bioscience 4806
      Selective allosteric inhibitor of IKK (IC50 values are 0.3 and 4.0 muM for IKKbeta and IKKalpha respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production in vitro and blocks NFkappaB dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis. Tocris Bioscience 4806
      Selective allosteric inhibitor of IKK; anti-inflammatory Tocris Bioscience 4806

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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