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Search term: RMMXLENWKUUMAY-UHFFFAOYSA-N (Found by InChIKey (full match))
ChemSpider 2D Image | Telmisartan | C33H30N4O2

Telmisartan

  • Molecular FormulaC33H30N4O2
  • Average mass514.617 Da
  • Monoisotopic mass514.236877 Da
  • ChemSpider ID59391

More details:

Featured data source
The Merck Index Online

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

[1,1'-Biphenyl]-2-carboxylic acid, 4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]- [ACD/Index Name]
144701-48-4 [RN]
4'[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid
4'-[(1,7'-Dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]-2-biphenylcarbonsäure [German] [ACD/IUPAC Name]
4'-[(1,7'-Dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]-2-biphenylcarboxylic acid [ACD/IUPAC Name]
4'-[(1,7'-Dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carbonsäure [German]
4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid
Acide 4'-[(1,7'-diméthyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)méthyl]-2-biphénylcarboxylique [French] [ACD/IUPAC Name]
acide 4'-[(1,7'-diméthyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)méthyl]biphényl-2-carboxylique [French]
Kinzalmono [Trade name]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

7144 [DBID]
BIBR 277 [DBID]
BIBR-277 [DBID]
C07710 [DBID]
D00627 [DBID]
KBio3_001958 [DBID]
KBioGR_001842 [DBID]
LS-44263 [DBID]
SPBio_002131 [DBID]
Spectrum2_001976 [DBID]
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      C09CA07 Wikidata Q733186

    • Target Organs:

      RAAS inhibitor; ACE inhibitor; PPAR agonist TargetMol T1570

    • Chemical Class:

      A member of the class of benzimidazoles used widely in the treatment of hypertension. ChEBI CHEBI:9434

    • Bio Activity:

      <p>AT<sub>1</sub> (Angiotensin II receptor type 1) antagonist / blocker (K<sub>i</sub> = 3.7 nM). It is also a PPAR&gamma; partial agonist.</p> <p>Shows anti-hypertensive effects.</p> <p>Recently investigated as part of COVID-19 compound repurposing.</p> Hello Bio HB2558
      7-TM Receptors Tocris Bioscience 5139
      ACE;PPAR gamma TargetMol T1570
      Angiogenesis; Endocrinology/ Hormones TargetMol T1570
      Angiotensin Receptor MedChem Express HY-13955
      Angiotensin Receptors Tocris Bioscience 5139
      Antagonist of the angiotensin II type 1 receptor (AT1) (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPAR? receptors; shown to improv e insulin sensitivity in rodents receiving high fat diets. Tocris Bioscience 5139
      Antagonist of the angiotensin II type 1 receptor (AT1) (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPAR? receptors; shown to improve insulin sensitivity in rodents receiving high fat diets. Tocris Bioscience 5139
      Antagonist of the angiotensin II type 1 receptor (AT1) (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPARgamma receptors; shown to improve insulin sensitivity in rodents receiving high fat diets. Tocris Bioscience 5139
      AT1 antagonist; PPAR? partial agonist Tocris Bioscience 5139
      AT1 antagonist; PPARgamma partial agonist Tocris Bioscience 5139
      GPCR/G protein MedChem Express HY-13955
      GPCR/G protein; MedChem Express HY-13955
      Peptide Receptors Tocris Bioscience 5139
      Telmisartan(BIBR 277) is an angiotensin II receptor antagonist (angiotensin receptor blocker, ARB) used in the management of hypertension. MedChem Express
      Telmisartan(BIBR 277) is an angiotensin II receptor antagonist (angiotensin receptor blocker, ARB) used in the management of hypertension.; IC50 Value: 9.2 nM [1]; Target: Angiotensin Receptor; in vitro: In intact RVSMC cells and in membrane preparations, telmisartan inhibits the binding of 125I-AngII to AT1 receptors in a concentrationdependent manner, with an IC50 of 9.2 ?0.8 nM. MedChem Express HY-13955

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.2±0.1 g/cm3
Boiling Point: 771.9±70.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.8 mmHg at 25°C
Enthalpy of Vaporization: 117.9±3.0 kJ/mol
Flash Point: 420.6±35.7 °C
Index of Refraction: 1.667
Molar Refractivity: 154.5±0.5 cm3
#H bond acceptors: 6
#H bond donors: 1
#Freely Rotating Bonds: 7
#Rule of 5 Violations: 2
ACD/LogP: 7.73
ACD/LogD (pH 5.5): 5.19
ACD/BCF (pH 5.5): 1899.12
ACD/KOC (pH 5.5): 2364.03
ACD/LogD (pH 7.4): 4.01
ACD/BCF (pH 7.4): 125.93
ACD/KOC (pH 7.4): 156.75
Polar Surface Area: 73 Å2
Polarizability: 61.3±0.5 10-24cm3
Surface Tension: 48.7±7.0 dyne/cm
Molar Volume: 414.9±7.0 cm3

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