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Search term: UTAJHKSGYJSZBR-UHFFFAOYSA-N (Found by InChIKey (full match))
ChemSpider 2D Image | ML-365 | C22H20N2O3

ML-365

  • Molecular FormulaC22H20N2O3
  • Average mass360.406 Da
  • Monoisotopic mass360.147400 Da
  • ChemSpider ID23082690

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

2-methoxy-N-[3-(3-methylbenzamido)phenyl]benzamide
2-Methoxy-N-{3-[(3-methylbenzoyl)amino]phenyl}benzamid [German] [ACD/IUPAC Name]
2-Methoxy-N-{3-[(3-methylbenzoyl)amino]phenyl}benzamide [ACD/IUPAC Name]
2-Méthoxy-N-{3-[(3-méthylbenzoyl)amino]phényl}benzamide [French] [ACD/IUPAC Name]
947914-18-3 [RN]
Benzamide, 2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]- [ACD/Index Name]
ML-365
[947914-18-3] [RN]
2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide
2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Ion Channels Tocris Bioscience 5337
      Membrane Tranporter/Ion Channel MedChem Express HY-12345
      Membrane Tranporter/Ion Channel; MedChem Express HY-12345
      ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3) with IC50 of 4 nM(thallium influx fluorescent assay) and 16 nM(automated electrophysiology assay). MedChem Express
      ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3) with IC50 of 4 nM(thallium influx fluorescent assay) and 16 nM(automated electrophysiology assay).; IC50 value: 4 nM/16 nM(thallium influx fluorescent assay/automated electrophysiology assay) [1]; Target: KCNK3 blocker; ML365 possesses more than 60-fold selectivity for inhibition of TASK1 over a closely-related, two-pore domain potassium channel, TASK3. MedChem Express HY-12345
      Non-selective / Other Potassium Channels Tocris Bioscience 5337
      Potassium Channel MedChem Express HY-12345
      Potassium Channels Tocris Bioscience 5337
      Potent and selective K2P3.1 TASK-1 channel blocker Tocris Bioscience 5337
      Potent and selective TASK-1 (K2P3.1/KCNK3) channel blocker (IC50 values are 4 and 390 nM at TASK-1 and TASK-3, respectively). Displays little or no inhibition at Kir2.1, voltage-gated potassium channe ls, KCNQ2 and KV11.1 (hERG). Tocris Bioscience 5337
      Potent and selective TASK-1 (K2P3.1/KCNK3) channel blocker (IC50 values are 4 and 390 nM at TASK-1 and TASK-3, respectively). Displays little or no inhibition at Kir2.1, voltage-gated potassium channels, KCNQ2 and KV11.1 (hERG). Tocris Bioscience 5337
      Potent and selective TASK-1 channel blocker Tocris Bioscience 5337
      Two-P Potassium Channels Tocris Bioscience 5337

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 429.9±40.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.0 mmHg at 25°C
Enthalpy of Vaporization: 68.5±3.0 kJ/mol
Flash Point: 213.8±27.3 °C
Index of Refraction: 1.666
Molar Refractivity: 106.9±0.3 cm3
#H bond acceptors: 5
#H bond donors: 2
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 0
ACD/LogP: 3.76
ACD/LogD (pH 5.5): 3.56
ACD/BCF (pH 5.5): 299.41
ACD/KOC (pH 5.5): 2061.17
ACD/LogD (pH 7.4): 3.56
ACD/BCF (pH 7.4): 299.41
ACD/KOC (pH 7.4): 2061.16
Polar Surface Area: 67 Å2
Polarizability: 42.4±0.5 10-24cm3
Surface Tension: 54.4±3.0 dyne/cm
Molar Volume: 287.5±3.0 cm3

Click to predict properties on the Chemicalize site


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