Found 1 result

Search term: ZVHNDZWQTBEVRY-UHFFFAOYSA-N (Found by InChIKey (full match))
ChemSpider 2D Image | Momelotinib | C23H22N6O2

Momelotinib

  • Molecular FormulaC23H22N6O2
  • Average mass414.460 Da
  • Monoisotopic mass414.180420 Da
  • ChemSpider ID24676202

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1056634-68-4 [RN]
Benzamide, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]- [ACD/Index Name]
Momelotinib [INN] [USAN]
Momelotinib [Spanish] [INN]
Momélotinib [French] [INN]
Momelotinibum [Latin] [INN]
N-(Cyanmethyl)-4-(2-{[4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)benzamid [German] [ACD/IUPAC Name]
N-(Cyanomethyl)-4-(2-{[4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)benzamide [ACD/IUPAC Name]
N-(Cyanométhyl)-4-(2-{[4-(4-morpholinyl)phényl]amino}-4-pyrimidinyl)benzamide [French] [ACD/IUPAC Name]
N-(cyanomethyl)-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)benzamide
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CYT387 [DBID]
  • Miscellaneous

    • Target Organs:

      JAK inhibitor TargetMol T1849

    • Chemical Class:

      A benzamide obtained by formal condensation of the carboxy group of 4-{2-[4-(morpholin-4-yl)anilino]pyrimidin-4-yl}benzoic acid with the primary amino group of aminoacetonitrile. It is an ATP-competit ive JAK1/JAK2 inhibitor with IC50 of 11 nM and 18 nM, respectively. Used for the treatment of patients with intermediate- or high-risk myelofibrosis. ChEBI CHEBI:91407

    • Bio Activity:

      CYT387(momelotinib) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. MedChem Express http://www.medchemexpress.com/CYT387-sulfate-salt.html
      JAK MedChem Express HY-10961
      JAK/STAT Signaling TargetMol T1849
      JAK/STAT Signaling; MedChem Express HY-10961
      JAK1/JAK2/JAK3 TargetMol T1849

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.646
Molar Refractivity: 116.4±0.3 cm3
#H bond acceptors: 8
#H bond donors: 2
#Freely Rotating Bonds: 7
#Rule of 5 Violations: 0
ACD/LogP: 1.22
ACD/LogD (pH 5.5): 1.85
ACD/BCF (pH 5.5): 13.87
ACD/KOC (pH 5.5): 210.54
ACD/LogD (pH 7.4): 1.97
ACD/BCF (pH 7.4): 18.46
ACD/KOC (pH 7.4): 280.20
Polar Surface Area: 103 Å2
Polarizability: 46.1±0.5 10-24cm3
Surface Tension: 63.6±3.0 dyne/cm
Molar Volume: 320.8±3.0 cm3

Click to predict properties on the Chemicalize site


Advertisement