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Nitrile-containing pharmaceuticals: target, mechanism of action, and their SAR studies . Xi Wang, Yuanxun Wang, Xuemin Li, Zhenyang Yu, Chun Song, Yunfei Du
, RSC Med. Chem.
, 2021
, 12
, 1650
Synthesis and pharmacological characterisation of arctigenin analogues as antagonists of AMPA and kainate receptors . Lisa-Maria Rečnik, Robert J. Thatcher, Shahida Mallah, Craig P. Butts, Graham L. Collingridge, Elek Molnár, David E. Jane, Christine L. Willis
, Org. Biomol. Chem.
, 2021
, 19
, 9154
Deciphering the binding mechanism of inhibitors of the SARS-CoV-2 main protease through multiple replica accelerated molecular dynamics simulations and free energy landscapes . Meng Li, Xinguo Liu, Shaolong Zhang, Shanshan Liang, Qinggang Zhang, Jianzhong Chen
, Phys. Chem. Chem. Phys.
, 2022
, 24
, 22129
A critical overview of computational approaches employed for COVID-19 drug discovery . Eugene N. Muratov, Rommie Amaro, Carolina H. Andrade, Nathan Brown, Sean Ekins, Denis Fourches, Olexandr Isayev, Dima Kozakov, José L. Medina-Franco, Kenneth M. Merz, Tudor I. Oprea, Vladimir Poroikov, Gisbert Schneider, Matthew H. Todd, Alexandre Varnek, David A. Winkler, Alexey V. Zakharov, Artem Cherkasov, Alexander Tropsha
, Chem. Soc. Rev.
, 2021
, 50
, 9121
Main and papain-like proteases as prospective targets for pharmacological treatment of coronavirus SARS-CoV-2 . Larysa V. Yevsieieva, Kateryna O. Lohachova, Alexander Kyrychenko, Sergiy M. Kovalenko, Volodymyr V. Ivanov, Oleg N. Kalugin
, RSC Adv.
, 2023
, 13
, 35500
Ru-Catalyzed C–H alkenylation on the arene ring of pirfenidone using pyridone as a directing group . Raziullah, Mohit Kumar, Ashfaq Ahmad, Himangsu Sekhar Dutta, Anushka Rastogi, Manoj Kumar Gangwar, Dipankar Koley
, Chem. Commun.
, 2022
, 58
, 3481
Regioselective α-arylation of coumarins and 2-pyridones with phenylhydrazines under transition-metal-free conditions . Parul Chauhan, Makthala Ravi, Shikha Singh, Prashant Prajapati, Prem P. Yadav
, RSC Adv.
, 2016
, 6
, 109
On the origins of SARS-CoV-2 main protease inhibitors . Yves L. Janin
, RSC Med. Chem.
, 2024
, 15
, 81
Access to 2-pyridinones comprising enaminonitriles via AgOAc promoted cascade reactions of thioesters with aminomethylene malononitriles . Chen Zhu, Jubao Zhou, Tianxing Li, Jiaxin Yang, Hui Jin, Lixin Zhang
, Org. Biomol. Chem.
, 2023
, 21
, 6881
Multi-component solvent-free cascade reaction of 2-cyanoacetamides: regioselective synthesis of pyridin-2-ones bearing quaternary centers . Lingbin Kong, Rong Huang, Haodan He, Yunxiang Fan, Jun Lin, Shengjiao Yan
, Green Chem.
, 2020
, 22
, 256