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105Stanton et al..
A small molecule that binds Hedgehog and blocks its signaling in human cells, Nature Chemical Biology, 2009 Sinha and Chen.
Purmorphamine activates the Hedgehog pathway by targeting Smoothened, Nature Chemical Biology, 2006 Oblak E. Zachary, G-Dayanandan Narendran, Wright Dennis L..
Tandem Metathesis Reactions of Oxabicyclo[2.2.1]heptenes: Studies on the Spirocyclic Core of Cyclopamine, Organic Letters, 2011 Tomoyo Sakata and James K. Chen.
Chemical ‘Jekyll and Hyde’s: small-molecule inhibitors of developmental signaling pathways, Chem. Soc. Rev., 2011, 40, 4318. Philipp Heretsch, Anita Büttner, Lito Tzagkaroulaki, Stefan Zahn, Barbara Kirchner and Athanassios Giannis.
Exo-Cyclopamine—a stable and potent inhibitor of hedgehog-signaling, Chem. Commun., 2011, 47, 7362. Brigitte Renoux, Thibaut Legigan, Souheyla Bensalma, Corinne Chadéneau, Jean-Marc Muller and Sébastien Papot.
A new cyclopamine glucuronide prodrug with improved kinetics of drug release, Org. Biomol. Chem., 2011, 9, 8459. Wang Jiangbo, Mook Robert A., Lu Jiuyi, Gooden David M., Ribeiro Anthony, Guo Anchen, Barak Larry S., Kim Lyerly H., Chen Wei.
Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling, Bioorganic & Medicinal Chemistry, 2012 Chen James K..
I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs, Nat. Prod. Rep., 2016