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1222Fabio Temussi, Giovanni Bassolino, Flavio Cermola, Marina DellaGreca, Maria Rosaria Iesce, Sara Montanaro, Lucio Previtera and Maria Rubino.
Investigation on the phototransformation of tadalafil in aqueous media. 6-Epimerization vs. solvent trapping reaction, Photochem. Photobiol. Sci., 2010, 9, 1139. PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil. Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective. Drug-to-genome-to-drug, step 2: reversing selectivity in a series of antiplasmodial compounds. In silico prediction of novel phosphodiesterase type-5 inhibitors derived from Sildenafil, Vardenafil and Tadalafil. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues. Differential effects of the phosphodiesterase type 5 inhibitors sildenafil, vardenafil, and tadalafil in rat aorta.