ChemSpider 2D Image | Amrubicin hydrochloride | C25H26ClNO9

Amrubicin hydrochloride

  • Molecular FormulaC25H26ClNO9
  • Average mass519.928 Da
  • Monoisotopic mass519.129639 Da
  • ChemSpider ID102849

  • defined stereocentres - 5 of 5 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(1S,3S)-3-Acetyl-3-amino-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 2-deoxy-β-D-erythro-pentopyranoside hydrochloride (1:1) [ACD/IUPAC Name]
(1S,3S)-3-Acetyl-3-amino-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl-2-desoxy-β-D-erythro-pentopyranosidhydrochlorid (1:1) [German] [ACD/IUPAC Name]
110311-30-3 [RN]
2-Désoxy-β-D-érythro-pentopyranoside de (1S,3S)-3-acétyl-3-amino-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tétracényle, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
5,12-Naphthacenedione, 9-acetyl-9-amino-7-[(2-deoxy-β-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-, (7S,9S)-, hydrochloride (1:1) [ACD/Index Name]
Amrubicin hydrochloride [USAN]
Calsed [Trade name]
(1S,3S)-3-acetyl-3-amino-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 2-deoxy-β-D-erythro-pentopyranoside hydrochloride (1:1)
(7S,9S)-9-acetyl-9-amino-7-[(2S,4S,5R)-4,5-dihydroxyoxan-2-yl]oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione and hydrochloride
(7S,9S)-9-acetyl-9-amino-7-[(2S,4S,5R)-4,5-dihydroxyoxan-2-yl]oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

EUL6MP8FZW [DBID]
SM-5887 [DBID]
SM 5887 [DBID]
SM5887 [DBID]
UNII:EUL6MP8FZW [DBID]
UNII-EUL6MP8FZW [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Amrubicin hydrochloride (SM-5887 hydrochloride) is a topoisomerase II inhibitor used in the treatment of lung cancer. MedChem Express
      Amrubicin hydrochloride (SM-5887 hydrochloride) is a topoisomerase II inhibitor used in the treatment of lung cancer.; Target: Topoisomerase II; SM-5887 is a novel anthracycline derivative. MedChem Express HY-B0067A
      Amrubicin hydrochloride (SM-5887 hydrochloride) is a topoisomerase II inhibitor used in the treatment of lung cancer.;Target: Topoisomerase IISM-5887 is a novel anthracycline derivative. The distribution of SM-5887 in the bladder mucosa and muscular layer was almost equal, but the concentration of its active metabolite, 13-OH derivative, was 5 to 10 times higher in the bladder mucosa than in the bladder muscular layer. The distributions of SM-5887 in the organs other than the bladder, that is, the cortex and medulla of kidney, heart, lung, liver, and spleen, were very low, and those of a 13-OH active metabolite were even lower. In addition, SM-5887 barely affected the normal bladder mucosa. In dogs instilled with 80 mg of SM-5887, no histological change was observed in the bladder mucosa and submucosal layer even after 6-hour retention at the highest concentration of 8,000 micrograms/ml [1]. SM-5887 is possibly most potent for the treatment of NSCLC, and that these drugs have less MedChem Express HY-B0067A
      Cell Cycle/DNA Damage MedChem Express HY-B0067A
      Cell Cycle/DNA Damage; MedChem Express HY-B0067A
      Topoisomerase MedChem Express HY-B0067A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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