ChemSpider 2D Image | EFONIDIPINE HCL | C34H39ClN3O7P

EFONIDIPINE HCL

  • Molecular FormulaC34H39ClN3O7P
  • Average mass668.116 Da
  • Monoisotopic mass667.221436 Da
  • ChemSpider ID106462

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

111011-53-1 [RN]
2-[Benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylate hydrochloride (1:1) [ACD/IUPAC Name]
2-[Benzyl(phenyl)amino]ethyl-5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridincarboxylathydrochlorid (1:1) [German] [ACD/IUPAC Name]
3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester, hydrochloride (1:1) [ACD/Index Name]
5-(5,5-Diméthyl-2-oxydo-1,3,2-dioxaphosphinan-2-yl)-2,6-diméthyl-4-(3-nitrophényl)-1,4-dihydro-3-pyridinecarboxylate de 2-[benzyl(phényl)amino]éthyle, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
EFONIDIPINE HCL
Efonidipine hydrochloride
EFONIDIPINE HYDROCHLORIDE, (R)-
EFONIDIPINE HYDROCHLORIDE, (S)-
[111011-53-1] [RN]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

3BR983K69O [DBID]
UNII:3BR983K69O [DBID]
084B99HW0I [DBID]
5C99NS3LEG [DBID]
CCRIS 4065 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Calcium Channel MedChem Express HY-12502B
      Efonidipine Hcl (NZ-105) is a dual T-type and L-type calcium channel blocker (CCB). MedChem Express
      Efonidipine Hcl (NZ-105) is a dual T-type and L-type calcium channel blocker (CCB).; IC50 value: ; Target: calcium channel blocker; in vitro: Efonidipine and nifedipine, but not other examined CCBs, also increased the N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP)-induced StAR mRNA, which reflects the action of adrenocorticotropic hormone, and efonidipine and R(-)-efonidipine enhanced the dbcAMP-induced DHEA-S production in NCI-H295R adrenocortical carcinoma cells [1]. MedChem Express HY-12502B
      Efonidipine Hcl (NZ-105) is a dual T-type and L-type calcium channel blocker (CCB).;IC50 value: ;Target: calcium channel blocker;In vitro: Efonidipine and nifedipine, but not other examined CCBs, also increased the N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP)-induced StAR mRNA, which reflects the action of adrenocorticotropic hormone, and efonidipine and R(-)-efonidipine enhanced the dbcAMP-induced DHEA-S production in NCI-H295R adrenocortical carcinoma cells [1]. I(Ca(T)) was blocked mainly by a tonic manner by nifedipine, by a use-dependent manner by mibefradil, and by a combination of both manners by efonidipine. IC50s of these Ca2+ channel antagonists to I(Ca(T)) and L-type Ca2+ channel current (I(Ca(L))) were 1.2 micromol/l and 0.14 nmol/l for nifedipine; 0.87 and 1.4 micromol/l for mibefradil, and 0.35 micromol/l and 1.8 nmol/l for efonidipine, respectively [4].;In vivo: Twenty hypertensive patients on chronic hemodialysis were given efonidipine 20-60 mg MedChem Express HY-12502B
      Membrane Tranporter/Ion Channel MedChem Express HY-12502B
      Membrane Tranporter/Ion Channel; MedChem Express HY-12502B

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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