ChemSpider 2D Image | Pramipexole hydrochloride | C10H19Cl2N3S

Pramipexole hydrochloride

  • Molecular FormulaC10H19Cl2N3S
  • Average mass284.249 Da
  • Monoisotopic mass283.067688 Da
  • ChemSpider ID106769

  • defined stereocentres - 1 of 1 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(6S)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine Dihydrochloride
(6S)-N6-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2,6-diamindihydrochlorid [German] [ACD/IUPAC Name]
(6S)-N6-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine dihydrochloride [ACD/IUPAC Name]
(6S)-N6-Propyl-4,5,6,7-tétrahydro-1,3-benzothiazole-2,6-diamine, dichlorhydrate [French] [ACD/IUPAC Name]
(6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine dihydrochloride
(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride
(S)-Pramipexole (hydrochloride)
104632-25-9 [RN]
2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, (6S)-, hydrochloride (1:2) [ACD/Index Name]
4R2HD0M28N
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

SND 919 [DBID]
SND 19 [DBID]
SND-919 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      A hydrochloride that is the anhydrous dihydrochloride salt of pramipexole. ChEBI CHEBI:51148

    • Bio Activity:

      7-TM Receptors Tocris Bioscience 4174
      Biochemicals & small molecules/Agonists & activators Hello Bio [HB1933]
      D3 Receptors Tocris Bioscience 4174
      Dopamine Receptor MedChem Express HY-17355
      Dopamine receptor agonist exhibiting selectivity for the D3 receptor (Ki values are 0.5, 3.3, 3.9 and 3.9 nM for D3, D2S, D2L and D4 receptors respectively). Exhibits negligible affinity for D1 and D5 receptors. Displays activity in the treatment of Parkinson's disease. Tocris Bioscience 4174
      Dopamine receptor agonist exhibiting selectivity for the D3 receptor (Ki values are 0.5, 3.3, 3.9 and 3.9 nM for D3, D2S, D2L and D4 receptors respectively). Exhibits negligible affinity for D1 and D5 receptors. Displays activity in the treatment of Parkinson's disease. Tocris Bioscience 4174
      Dopamine Receptors Tocris Bioscience 4174
      GPCR/G protein MedChem Express HY-17355
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-17355
      Pramipexole 2Hcl is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively. MedChem Express http://www.medchemexpress.com/Darunavir.html, HY-17355
      Pramipexole 2Hcl is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively. ;IC50 Value: 3.9 nM(D2S); 2.2 nM(D2L); 0.5 nM(D3); 5.1 nM(D4);Target: Dopamine ReceptorPramipexole dihydrochloride is a dopamine receptor agonist with selectivity for the D3 receptor (Ki values are 3.9, 3.3, 0.5 and 3.9 nM for D2L, D2S, D3 and D4 receptors respectively). Pramipexole dihydrochloride exhibits negligable affinity for D1 and D5 receptors. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibits the activation of apoptotic pathways. Pramipexole displays activity in the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS). MedChem Express HY-17355
      Receptors & Transporters/G protein coupled receptors/Dopamine/D2-like/D<sub>3</sub> Hello Bio [HB1933]
      Selective D<sub>3</sub> receptor agonist Hello Bio [HB1933]
      Selective D3 agonist Tocris Bioscience 4174

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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