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Mosapride Citrate

Molecular FormulaC₂₇H₃₃ClFN₃O₁₀
Average mass614.016 Da
Monoisotopic mass613.183838 Da
ChemSpider ID106779

More details:

Names and Synonyms
Database ID(s)

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(±)-4-Amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide Citrate

112885-42-4 [RN]

2-Hydroxy-1,2,3-propantricarbonsäure --4-amino-5-chlor-2-ethoxy-N-{[4-(4-fluorbenzyl)-2-morpholinyl]methyl}benzamid (1:1) [German] [ACD/IUPAC Name]

4-Amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)-2-morpholinyl]methyl}benzamide 2-hydroxy-1,2,3-propanetricarboxylate (1:1) [ACD/IUPAC Name]

4-Amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)morpholin-2-yl]methyl}benzamide 2-hydroxypropane-1,2,3-tricarboxylate (1:1)

4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)morpholin-2-yl]methyl}benzamide 2-hydroxypropane-1,2,3-tricarboxylate (salt)

Acide 2-hydroxy-1,2,3-propanetricarboxylique - 4-amino-5-chloro-2-éthoxy-N-{[4-(4-fluorobenzyl)-2-morpholinyl]méthyl}benzamide (1:1) [French] [ACD/IUPAC Name]

Benzamide, 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) [ACD/Index Name]

Mosapride (citrate)

Mosapride Citrate

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(4-amino-5-chloro-2-ethoxyphenyl)-N-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)carboxamide, 2-hydroxypropane-1,2,3-tricarboxylic acid

[112885-42-4] [RN]

1227162-82-4 [RN]

156925-25-6 [RN]

2-hydroxypropane-1,2,3-tricarboxylic acid

2-hydroxypropane-1,2,3-tricarboxylic acid; 4-amino-5-chloro-2-ethoxy-N-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)benzamide

4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide 2-hydroxypropane-1,2,3-tricarboxylate

4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]benzamide citrate

4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide

4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide and 2-hydroxypropane-1,2,3-tricarboxylic acid

4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide;2-hydroxypropane-1,2,3-tricarboxylic acid

636582-62-2 [RN]

AS-4370 citrate

Benzamide, 4-amino-5-chloro-2-ethoxy-N-((4-((4-fluorophenyl)methyl)-2-morpholinyl)methyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

Citric acid [ACD/IUPAC Name] [Wiki]

CU9316000

Gasmotin [Trade name]

Gasmotin citrate

MFCD01666680

Mosapride [INN] [Wiki]

MosaprideCitrate

Moza citrate

Moza citrate;TAK-370 citrate;AS-4370 citrate;Gasmotin citrate

Normethylclozapine | Norclozapine |

TAK-370 citrate

TAK-370, AS-4370, Gasmot

TAK-370;AS-4370;Gasmotin

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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

MF497J489P [DBID]

UNII:MF497J489P [DBID]

AS 4370 [DBID]

AS-4370 [DBID]

D01994 [DBID]

TAK-370 [DBID]

Experimental data
Predicted - ACD/Labs
Predicted - ChemAxon
Predicted - Mcule

Experimental Physico-chemical Properties

Bio Activity:

5-HT Receptor MedChem Express HY-B0189A

5-HT Receptors Tocris Bioscience 2844

5-HT4 receptor agonist and 5-HT3 receptor antagonist. Displays no activity at D2,α1, α2, 5-HT1 and 5-HT2 receptors. Shows anti-emetic effects. Hello Bio HB1737

5-HT4 receptor agonist. Also 5-HT3 antagonist. Hello Bio HB1737

5-HT4 agonist and 5-HT3 antagonist Tocris Bioscience 2844

5-HT4 receptor agonist and 5-HT3 receptor antagonist. Displays no activity at D2, ?1, ?2, 5-HT1 and 5-HT2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric m otor actvity in conscious dogs. Tocris Bioscience 2844

5-HT4 receptor agonist and 5-HT3 receptor antagonist. Displays no activity at D2, ?1, ?2, 5-HT1 and 5-HT2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs. Tocris Bioscience 2844

5-HT4 receptor agonist and 5-HT3 receptor antagonist. Displays no activity at D2, alpha1, alpha2, 5-HT1 and 5-HT2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs. Tocris Bioscience 2844

5-HT4 Receptors Tocris Bioscience 2844

7-TM Receptors Tocris Bioscience 2844

Biochemicals & small molecules/Agonists & activators Hello Bio HB1737

GPCR/G protein MedChem Express HY-B0189A

GPCR/G protein; Neuronal Signaling; MedChem Express HY-B0189A

Ion channels/Ligand-gated ion channel/5-HT3/INACTIVE 5-HT3 Hello Bio HB1737

Mosapride citrate is a gastroprokinetic agent that acts as a selective 5HT4 agonist. MedChem Express

Mosapride citrate is a gastroprokinetic agent that acts as a selective 5HT4 agonist.; Target: 5HT4 ; Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist. MedChem Express HY-B0189A

Mosapride citrate is a gastroprokinetic agent that acts as a selective 5HT4 agonist.;Target: 5HT4 Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist. The major active metabolite of mosapride, known as M1, additionally acts as a 5HT3 antagonist, which accelerates gastric emptying throughout the whole of the gastrointestinal tract in humans, and is used for the treatment of gastritis, gastro-oesophageal reflux disease, functional dyspepsia and irritable bowel syndrome. It is recommended to be taken on an empty stomach (i.e. at least one hour before food or two hours after food).;In addition to its prokinetic properties, mosapride also exerts anti-inflammatory effects on the gastrointestinal tract which may contribute to some of its therapeutic effects. Mosapride also promotes neurogenesis in the gastrointestinal tract which may prove useful in certain bowel disorders. The neurogenesis is due to mosapride's effect on the 5-HT4 receptor where it acts as an ag MedChem Express HY-B0189A

Receptors & Transporters/G protein coupled receptors/5-HT/5-HT4 Hello Bio HB1737

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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Click to predict properties on the Chemicalize site

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Mosapride Citrate

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