ChemSpider 2D Image | LY-300168 MONOHYDROCHLORIDE | C19H21ClN4O3

LY-300168 MONOHYDROCHLORIDE

  • Molecular FormulaC19H21ClN4O3
  • Average mass388.848 Da
  • Monoisotopic mass388.130219 Da
  • ChemSpider ID112582

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

143692-48-2 [RN]
5-(4-Aminophenyl)-N,8-dimethyl-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-carboxamidhydrochlorid (1:1) [German] [ACD/IUPAC Name]
5-(4-Aminophenyl)-N,8-dimethyl-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide hydrochloride (1:1) [ACD/IUPAC Name]
5-(4-Aminophényl)-N,8-diméthyl-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazépine-7-carboxamide, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
7H-1,3-Dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide, 5-(4-aminophenyl)-8,9-dihydro-N,8-dimethyl-, hydrochloride (1:1) [ACD/Index Name]
LY-300168 MONOHYDROCHLORIDE
[143692-48-2] [RN]
1-(4-Aminophenyl)-3-methylcarbamyl- 4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepinehydr
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

91HGG22IDM [DBID]
UNII:91HGG22IDM [DBID]
GYKI 53655 [DBID]
UN 2811 [DBID]
UN2811 [DBID]
  • References
  • Experimental Physico-chemical Properties

    • Experimental Solubility:

      Soluble in water (100mM, gentle warming) and in DMSO (100 mM) Hello Bio HB0312
      Soluble to 100 mM in water and to 100 mM in DMSO Tocris Bioscience 2555
  • Miscellaneous

    • Bio Activity:

      <p>Non-competitive AMPA and kainate receptor antagonist. Analog of <a href="gyki-52466.html" title="GYKI 52466 hydrochloride | Hello Bio" target="_self">GYKI 52466</a>.</p> <p>GYKI 53655 acts via an allosteric site at the AMPAR and&nbsp;inhibits channel gating downstream of glutamate binding.</p> <p><br />The compound inhibits AMPA - mediated&nbsp;response in cells expressing human GluR1(GluA1) and GluR4(GluA4) (IC<sub>50</sub> values are 6 &micro;M and 5 &micro;M for GluA1 and GluA4 subunits respectively).</p> <p>At higher concentrations, GYKI 53655 also blocks kainate GluK3 homomeric receptors (IC<sub>50</sub> = 63 &mu;M) and GluK2b(R)/GluK3 heteroreceptors (IC<sub>50</sub> = 32 &mu;M).</p> <p><br />Active <em>in vivo.</em> Shows anticonvulsive and neuroprotective effects.</p> Hello Bio HB0312
      <p>Non-competitive AMPA and kainate receptor antagonist. Analog of <a href=gyki-52466.html title=GYKI 52466 hydrochloride | Hello Bio target=_self>GYKI 52466</a>.</p> <p>GYKI 53655 acts via an allosteric site at the AMPAR and&nbsp;inhibits channel gating downstream of glutamate binding.</p> <p><br />The compound inhibits AMPA - mediated&nbsp;response in cells expressing human GluR1(GluA1) and GluR4(GluA4) (IC<sub>50</sub> values are 6 &micro;M and 5 &micro;M for GluA1 and GluA4 subunits respectively).</p> <p>At higher concentrations, GYKI 53655 also blocks kainate GluK3 homomeric receptors (IC<sub>50</sub> = 63 &mu;M) and GluK2b(R)/GluK3 heteroreceptors (IC<sub>50</sub> = 32 &mu;M).</p> <p><br />Active <em>in vivo.</em> Shows anticonvulsive and neuroprotective effects.</p> Hello Bio HB0312
      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio HB0312
      Glutamate (Ionotropic) Receptors Tocris Bioscience 2555
      Ion Channels Tocris Bioscience 2555
      Ion channels/Ligand-gated ion channel/Ionotropic glutamate receptors/AMPA Hello Bio HB0312
      Ion channels/Ligand-gated ion channel/Ionotropic glutamate receptors/Kainate Hello Bio HB0312
      Ligand-gated Ion Channels Tocris Bioscience 2555
      Non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466 (Cat. No. 1454). Prolongs the survival time after MgCl2- induced global cerebral ischemia. Exhibits anticonvulsant activity. Also blocks GluK3 homomeric receptors (IC50 = 63 ?M) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 ?M) at high concentrations. Tocris Bioscience 2555
      Non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466 (Cat. No. 1454). Prolongs the survival time after MgCl2- induced global cerebral ischemia. Exhibits anticonvulsant activity. Also blocks GluK3 homomeric receptors (IC50 = 63 ?M) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 ?M) at high concentrations. Tocris Bioscience 2555
      Non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466 (Cat. No. 1454). Prolongs the survival time after MgCl2- induced global cerebral ischemia. Exhibits anticonvulsant activity. Also blocks GluK3 homomeric receptors (IC50 = 63 muM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 muM) at high concentrations. Tocris Bioscience 2555
      Non-competitive AMPA receptor antagonist Tocris Bioscience 2555
      Non-competitive AMPA receptor antagonist Hello Bio HB0312

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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