ChemSpider 2D Image | Xanomeline oxalate | C16H25N3O5S

Xanomeline oxalate

  • Molecular FormulaC16H25N3O5S
  • Average mass371.452 Da
  • Monoisotopic mass371.151489 Da
  • ChemSpider ID13957480

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1,4-Benzenediamine, ethanedioate (1:1) [ACD/Index Name]
141064-23-5 [RN]
5-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1-methyl-1,2,3,6-tetrahydropyridine ethanedioate (1:1) [ACD/IUPAC Name]
5-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1-méthyl-1,2,3,6-tétrahydropyridine oxalate (1:1) [French] [ACD/IUPAC Name]
5-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1-methyl-1,2,3,6-tetrahydropyridine; oxalic acid
Ethandisäure --5-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1-methyl-1,2,3,6-tetrahydropyridin (1:1) [German] [ACD/IUPAC Name]
Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl-, ethanedioate (1:1) [ACD/Index Name]
Xanomeline (oxalate)
Xanomeline oxalate
?3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl-pyridine, ethanedioate
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

JF5A0PK3G5 [DBID]
UNII:JF5A0PK3G5 [DBID]
UNII-DJ1F4R673N [DBID]
UNII-JF5A0PK3G5 [DBID]
  • Experimental Physico-chemical Properties

    • Experimental Solubility:

      10 mM in DMSO MedChem Express HY-13410
      100 mM in DMSO MedChem Express HY-13410
      Soluble to 10 mM in water and to 100 mM in DMSO Tocris Bioscience 3569
      Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO Tocris Bioscience 3569
  • Miscellaneous

    • Bio Activity:

      7-TM Receptors Tocris Bioscience 3569
      Acetylcholine (Muscarinic) Receptors Tocris Bioscience 3569
      Acetylcholine Muscarinic Receptors Tocris Bioscience 3569
      Functionally selective M1 agonist Tocris Bioscience 3569
      Functionally selective muscarinic M1 receptor agonist (EC50 values are 0.3, 5, 42, 52 and 92.5 nM at M1, M3, M5, M4 and M2 receptors respectively). Displays a complex pharmacological profile: reversib le and wash-resistant binding, resulting in full agonist activity at M1; delayed wash-resistant partial agonist activity at M2; and delayed wash-resistant full agonist activity at M4. Exhibits antipsy chotic activity, and improves cognitive deficits and behavioral disturbances in Alzheimer's disease and schizophrenia. Tocris Bioscience 3569
      Functionally selective muscarinic M1 receptor agonist (EC50 values are 0.3, 5, 42, 52 and 92.5 nM at M1, M3, M5, M4 and M2 receptors respectively). Displays a complex pharmacological profile: reversible and wash-resistant binding, resulting in full agonist activity at M1; delayed wash-resistant partial agonist activity at M2; and delayed wash-resistant full agonist activity at M4. Exhibits antipsychotic activity, and improves cognitive deficits and behavioral disturbances in Alzheimer's disease and schizophrenia. Tocris Bioscience 3569
      GPCR/G protein MedChem Express HY-13410
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-13410
      M1 Receptors Tocris Bioscience 3569
      mAChR MedChem Express HY-13410
      Xanomeline(LY246708) is a selective M1 muscarinic receptor agonist. MedChem Express
      Xanomeline(LY246708) is a selective M1 muscarinic receptor agonist.; IC50 value:; Target: M1 muscarinic receptor; in vitro: Xanomeline had high affinity for muscarinic receptors in brain homogenates, but had substantially less or no affinity for a number of other neurotransmitter receptors and uptake sites. MedChem Express HY-13410
      Xanomeline(LY246708) is a selective M1 muscarinic receptor agonist.;IC50 value:;Target: M1 muscarinic receptor;In vitro: Xanomeline had high affinity for muscarinic receptors in brain homogenates, but had substantially less or no affinity for a number of other neurotransmitter receptors and uptake sites. In cells stably expressing genetic m1 receptors, xanomeline increased phospholipid hydrolysis in CHO, BHK and A9 L cells to 100, 72 and 55% of the nonselective agonist carbachol. In isolated tissues, xanomeline had high affinity for M1 receptors in the rabbit vas deferens (IC50 = 0.006 nM), low affinity for M2 receptors in guinea pig atria (EC50 = 3 microM), was a weak partial agonist in guinea pig ileum and was neither an agonist nor antagonist in guinea pig bladder [1]. Xanomeline produced small increases in striatal acetylcholine levels and did not antagonize the large increases in acetylcholine produced by the nonselective muscarinic agonist oxotremorine, indicating that xanome MedChem Express HY-13410

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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