ChemSpider 2D Image | gf 120918a | C34H34ClN3O5

gf 120918a

  • Molecular FormulaC34H34ClN3O5
  • Average mass600.104 Da
  • Monoisotopic mass599.218689 Da
  • ChemSpider ID148922

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

143851-98-3 [RN]
4'-(2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl)-5-methoxy-9-oxo-4-acridancarboxanilide Monohydrochloride
4-Acridinecarboxamide, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-, hydrochloride (1:1) [ACD/Index Name]
Elacridar hydrochloride
gf 120918a
N-(4-(2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl)phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide Hydrochloride
N-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihydroacridine-4-carboxamide Hydrochloride
N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]phenyl}-5-methoxy-9-oxo-9,10-dihydroacridine-4-carboxamide hydrochloride
N-{4-[2-(6,7-Dimethoxy-3,4-dihydro-2(1H)-isochinolinyl)ethyl]phenyl}-5-methoxy-9-oxo-9,10-dihydro-4-acridincarboxamidhydrochlorid (1:1) [German] [ACD/IUPAC Name]
N-{4-[2-(6,7-Diméthoxy-3,4-dihydro-2(1H)-isoquinoléinyl)éthyl]phényl}-5-méthoxy-9-oxo-9,10-dihydro-4-acridinecarboxamide, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
GF 120918 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold for research purposes under agreement from GlaxoSmithKline. Tocris Bioscience 4646

    • Bio Activity:

      Elacridar Hcl (GF120918; GW0918) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. MedChem Express
      Elacridar Hcl (GF120918; GW0918) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules.; IC50 value:; Target: P-glycoprotein ; In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog plasma. MedChem Express HY-50880
      Elacridar Hcl (GF120918; GW0918) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules.;IC50 value:;Target: P-glycoprotein ;In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog plasma. GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro, with IC(50) values well above concentrations anticipated to be achieved in vivo. Together, these data confirm the utility of GF120918A as a tool P-glycoprotein inhibitor in preclinical species and offer additional guidance on preclinical dose regimens likely to produce P-glycoprotein-mediated effects. MedChem Express HY-50880
      Membrane Tranporter/Ion Channel MedChem Express HY-50880
      Membrane Tranporter/Ion Channel; MedChem Express HY-50880
      Multidrug Transporters Tocris Bioscience 4646
      P-glycoprotein MedChem Express HY-50880
      P-glycoprotein (P-gp/ABCG1) inhibitor. Blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin (Cat. No. 2252) and vincristine (Cat. No. 1257) in CHRC5 cells. Also inhibits breast cancer resistance protein (BCRP/ABCG2). Orally active. Tocris Bioscience 4646
      P-glycoprotein (P-gp/ABCG1) inhibitor. Blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin (Cat. No. 2252) and vincristine (Cat. No. 1257) in CHRC5 cells. Also inhibits breast cancer resistance protein (BCRP/ABCG2). Orally active. Tocris Bioscience 4646
      P-gp inhibitor Tocris Bioscience 4646
      Transporters Tocris Bioscience 4646

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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