ChemSpider 2D Image | MFCD04974534 | C23H26ClNO

MFCD04974534

  • Molecular FormulaC23H26ClNO
  • Average mass367.912 Da
  • Monoisotopic mass367.170288 Da
  • ChemSpider ID153645

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1021868-92-7 [RN]
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-, hydrochloride (1:1) [ACD/Index Name]
3-(N-Benzyl-N-isopropyl)amino-1-(naphthalen-2-yl)propan-1-one hydrochloride
3-[Benzyl(isopropyl)amino]-1-(2-naphthyl)-1-propanone hydrochloride (1:1) [ACD/IUPAC Name]
3-[Benzyl(isopropyl)amino]-1-(2-naphthyl)-1-propanonhydrochlorid (1:1) [German] [ACD/IUPAC Name]
3-[Benzyl(isopropyl)amino]-1-(2-naphthyl)propan-1-one hydrochloride (1:1)
3-[Benzyl(isopropyl)amino]-1-(2-naphtyl)-1-propanone, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
3-[BENZYL(ISOPROPYL)AMINO]-1-(NAPHTHALEN-2-YL)PROPAN-1-ONE HYDROCHLORIDE
3-[BENZYL(PROPAN-2-YL)AMINO]-1-(NAPHTHALEN-2-YL)PROPAN-1-ONE HYDROCHLORIDE
58753-54-1 [RN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

EU-0100844 [DBID]
UN2811 [DBID]
Z4626_SIGMA [DBID]
ZM 39923 [DBID]
ZM39923 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold with the permission of AstraZeneca Ltd. Tocris Bioscience 1367

    • Target Organs:

      JAK inhibitor; EGFR inhibitor TargetMol T2460

    • Bio Activity:

      Enzymes Tocris Bioscience 1367
      JAK MedChem Express HY-12589
      JAK Kinase Tocris Bioscience 1367
      JAK/STAT Signaling MedChem Express HY-12589
      JAK/STAT Signaling; MedChem Express HY-12589
      Kinases Tocris Bioscience 1367
      Potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3). pIC50 values are 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Breaks down in neutral buffer (t? = 36 mins, pH 7.43, 25?C) to form ZM 449829 (Cat. No. 1366). Tocris Bioscience 1367
      Potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3). pIC50 values are 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Breaks down in neutral buffer (t½ = 36 mins, pH 7.4 3, 25°C) to form ZM 449829 (Cat. No. 1366). Tocris Bioscience 1367
      Potent, selective JAK3 inhibitor Tocris Bioscience 1367
      TGM2;JAK3;EGFR;JAK1 TargetMol T2460
      Tyrosine Kinase/Adaptors; JAK/STAT Signaling TargetMol T2460
      ZM39923 hydrochloride is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR, also found to be sensitive to transglutaminase. MedChem Express
      ZM39923 hydrochloride is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR, also found to be sensitive to transglutaminase.; IC50 value: 4.4/7.1 (pIC50); Target: JAK1/3; in vitro: ZM39923 is a JAK3 inhibitor. MedChem Express HY-12589

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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