ChemSpider 2D Image | doxycycline hydrochloride | C22H25ClN2O8

doxycycline hydrochloride

  • Molecular FormulaC22H25ClN2O8
  • Average mass480.896 Da
  • Monoisotopic mass480.129944 Da
  • ChemSpider ID16736953

  • defined stereocentres - 6 of 6 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(4S-(4a,4aa,5a,5aa,6a,12aa))-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride
(4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride
(4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracencarboxamidhydrochlorid (1:1) [German] [ACD/IUPAC Name]
(4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracenecarboxamide hydrochloride
(4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracenecarboxamide hydrochloride (1:1) [ACD/IUPAC Name]
(4S,4aR,5S,5aR,6R,12aS)-4-(Diméthylamino)-3,5,10,12,12a-pentahydroxy-6-méthyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-tétracènecarboxamide, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
(4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride (1:1)
10592-13-9 [RN]
234-198-7 [EINECS]
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)-, hydrochloride (1:1) [ACD/Index Name]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

10592-13-9 ; 100929-47-3 [DBID]
10592-13-9; 100929-47-3 [DBID]
10592-13-9100929-47-3 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      The hydrochloride salt of doxycycline. ChEBI https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:652992, CHEBI:652992

    • Bio Activity:

      Antibacterial MedChem Express HY-N0565A
      Anti-infection MedChem Express HY-N0565A
      Anti-infection; MedChem Express HY-N0565A
      Broad-spectrum antibiotic and MMP inhibitor; tetracycline derivative. Increases and promotes smooth muscle cell adhesion; inhibits proliferation and migration. Protects the microvasculature by inhibit ing plasminogen systems. Tocris Bioscience 4090
      Broad-spectrum antibiotic and MMP inhibitor; tetracycline derivative. Increases and promotes smooth muscle cell adhesion; inhibits proliferation and migration. Protects the microvasculature by inhibiting plasminogen systems. Tocris Bioscience 4090
      Broad-spectrum MMP inhibitor; tetracycline derivative Tocris Bioscience 4090
      Doxycycline Hydrochloride is a synthetic tetracycline derivative with similar antimicrobial activity. MedChem Express
      Doxycycline Hydrochloride is a synthetic tetracycline derivative with similar antimicrobial activity.; Target: Antibacterial; Doxycycline is a tetracycline antibiotic which is commonly used to treat a variety of infections. MedChem Express HY-N0565A
      Doxycycline Hydrochloride is a synthetic tetracycline derivative with similar antimicrobial activity.;Target: AntibacterialDoxycycline is a tetracycline antibiotic which is commonly used to treat a variety of infections. Doxycycline treatment resulted in a 96% loss of Wolbachia, as determined by real time PCR from microfilariae. The mechanism of doxycycline is similar to that in other filarial species, i.e., a predominant blockade of embryogenesis, leading to a decline of microfilariae according to their half-life [1]. Doxycycline treatment inhibits the activity of tissue MMP and attenuates the decrease in the collagen content in aortas of mice haploinsufficient for collagen III, as well as prevents the development of stress-induced vessel pathology. The results suggest that doxycycline merits clinical testing as a treatment for vEDS [2]. One person from the doxycycline group died from HIV infection. Five (doxycycline) and 11 (placebo) individuals were absent at the time of ultraso MedChem Express HY-N0565A
      Enzymes Tocris Bioscience 4090
      Matrix Metalloprotease Tocris Bioscience 4090
      Proteases Tocris Bioscience 4090

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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