Jump to main content Jump to site nav

Visit the new version of ChemSpider

Try beta.chemspider

NUTLIN

Molecular FormulaC₃₀H₃₀Cl₂N₄O₄
Average mass581.490 Da
Monoisotopic mass580.164429 Da
ChemSpider ID187530

More details:

Names and Synonyms
Database ID(s)

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

2-Piperazinone, 4-[[4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]- [ACD/Index Name]

4-({4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one

4-[[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazol-1-yl]-oxomethyl]-2-piperazinone

4-[4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one

4-{[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazol-1-yl]carbonyl}-2-piperazinone [ACD/IUPAC Name]

4-{[4,5-Bis(4-chlorophényl)-2-(2-isopropoxy-4-méthoxyphényl)-4,5-dihydro-1H-imidazol-1-yl]carbonyl}-2-pipérazinone [French] [ACD/IUPAC Name]

4-{[4,5-Bis(4-chlorphenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazol-1-yl]carbonyl}-2-piperazinon [German] [ACD/IUPAC Name]

548472-68-0 [RN]

NUTLIN

Nutlin-3

More...

Nutlin-3a

Nutlin-3b

Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-;4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

(-)-4-(4,5-bis-(4-Chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl)piperazine-2-one

()-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one

(-)-Nutlin-3

(??)-nutlin-3

(+)-Nutlin-3

(±)-4-[4,5-bis-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]piperazin-2-one

(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one

(±)-Nutlin3

(2R,4S,4aR)-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydro-2H-pyrano[3,2-c]isochromen-6-one

[548472-68-0] [RN]

115063-92-8 [RN]

2-Piperazinone, 4-[[4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1 H -imidazol-1-yl]carbonyl]-

2-Piperazinone,4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-,rel-

4-((4,5-bis(4-chlorophenyl)-4,5-dihydro-2-(4-methoxy-2-(1-methylethoxy)phenyl)-1h-imidazol-1-yl)carbonyl)-2-piperazinone

4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

4-[(4S,5R)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

4-[[4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1h-imidazol-1-yl]carbonyl]-2-piperazinone

4-[[-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone

4-[4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one

4-[4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDROIMIDAZOLE-1-CARBONYL]PIPERAZIN-2-ONE

4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

53IA0V845C

63347-83-1 [RN]

675576-97-3 [RN]

675576-98-4 [RN]

890090-75-2 [RN]

FJA1772CVW

L7C92IOE65

MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem

MDM2 Inhibitor IV

MFCD07784509 [MDL number]

MFCD11977784

MFCD14636430 [MDL number]

nitlin-3

nutlin 3

nutlin 3(random configuration)

Nutlin 3,MDM2 Antagonist

Nutlin 3a

Nutlin 3b

Nutlin3

Nutlin-3a chiral

Nutlin-3a;Nutlin 3a

PI-44592

PI-44596

PIPERAZINONE,4-[[(4R,5S)-4,5-BIS(4-CHLOROPHENYL)-4,5-DIHYDRO-2-[4-METHOXY-2-(1-METHYLETHOXY)PHENYL]-1H-IMIDAZOL-1-YL]CARBONYL]-

Less...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

N6287_SIGMA [DBID]

nchembio774-comp1 [DBID]

Experimental data
Predicted - ACD/Labs
Predicted - ChemAxon
Predicted - Mcule

Miscellaneous
- Target Organs:
  
  Mdm2 inhibitor;p53 inhibitor TargetMol T2158
- Bio Activity:
  
  Apoptosis TargetMol T2158
  
  MDM2/p53 TargetMol T2158

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density:	1.4±0.1 g/cm³
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction:	1.648
Molar Refractivity:	155.2±0.5 cm³
#H bond acceptors:	8
#H bond donors:	1
#Freely Rotating Bonds:	6
#Rule of 5 Violations:	1

ACD/LogP:	2.77
ACD/LogD (pH 5.5):	4.40
ACD/BCF (pH 5.5):	1290.98
ACD/KOC (pH 5.5):	5865.52
ACD/LogD (pH 7.4):	4.40
ACD/BCF (pH 7.4):	1291.91
ACD/KOC (pH 7.4):	5869.71
Polar Surface Area:	83 Å²
Polarizability:	61.5±0.5 10^-24cm³
Surface Tension:	49.4±7.0 dyne/cm
Molar Volume:	426.7±7.0 cm³

Click to predict properties on the Chemicalize site

Patents	Personal Collections
Publication or Magazine Article	Web-based Article (blog or commentary)
Available Chemicals Databases	Biological Properties
Chemical Reactions	Chemical Safety Data
Drugs or Compounds in Development	Imaging Agents
Information Aggregators	Journal Publishers via MeSH
Ligand/binding/crystal Structure Databases	Metabolic Pathways
Molecular Libraries Screening Center Network	Natural Products
NIH Substance Repository	Physical Properties (including SAR/QSAR databases)
Protein 3D Structures	Spectroscopy Databases
Substance Vendors	Theoretical Properties
Toxicology/Environmental Databases	Virtual Library

NUTLIN

More details:

Target Organs:

Bio Activity:

Search ChemSpider:

Search Google: