ChemSpider 2D Image | PFT-alpha | C16H19BrN2OS

PFT-α

  • Molecular FormulaC16H19BrN2OS
  • Average mass367.304 Da
  • Monoisotopic mass366.040131 Da
  • ChemSpider ID19952120

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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)- benzothiazolyl)ethanone hydrobromide
2-(2-Imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3(2H)-yl)-1-(4-methylphenyl)ethanone hydrobromide (1:1) [ACD/IUPAC Name]
2-(2-Imino-4,5,6,7-tétrahydro-1,3-benzothiazol-3(2H)-yl)-1-(4-méthylphényl)éthanone, bromhydrate (1:1) [French] [ACD/IUPAC Name]
2-(2-Imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3(2H)-yl)-1-(4-methylphenyl)ethanonhydrobromid (1:1) [German] [ACD/IUPAC Name]
63208-82-2 [RN]
D213B92S1Y
Ethanone, 1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-, hydrobromide (1:1) [ACD/Index Name]
PFT-α
Pifithrin-?
Pifithrin-a
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

P4359_SIGMA [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      5 Axon Medchem [1871]
      H303;H313;H317;H333;H334;H335;H373 Axon Medchem [1871]
      no pictogram Axon Medchem [1871]
      P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P340 Axon Medchem [1871]
      Warning Axon Medchem [1871]
    • Target Organs:

      p53 inhibitor TargetMol T2707
    • Bio Activity:

      Apoptosis MedChem Express HY-15484
      Apoptosis TargetMol T2707
      Apoptosis; MedChem Express HY-15484
      Cell Biology Tocris Bioscience 1267
      Cell Cycle Tocris Bioscience 1267
      Inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protect s mice from the side-effects of cancer therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR t arget gene CYP1A1 (EC50 = 1.1 ?M). Cyclic analog available (Cat. No. 3843). Tocris Bioscience 1267
      Inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of cancer therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 ?M). Cyclic analog available (Cat. No. 3843). Tocris Bioscience 1267
      Inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of cancer therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 muM). Cyclic analog available (Cat. No. 3843). Tocris Bioscience 1267
      MDM-2, p53 MedChem Express HY-15484
      p53 Tocris Bioscience 1267
      p53 TargetMol T2707
      p53 inhibitor. Also aryl hydrocarbon receptor agonist Tocris Bioscience 1267
      Pifithrin-? is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.; IC50 Value:; Target: MDM2/p53; Pifithrin-? (PFT?) was originally thought to be a specific inhibitor of signaling by the tumor suppressor protein p53. MedChem Express HY-15484

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

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