ChemSpider 2D Image | JNJ-38877605 | C19H13F2N7

JNJ-38877605

  • Molecular FormulaC19H13F2N7
  • Average mass377.350 Da
  • Monoisotopic mass377.120056 Da
  • ChemSpider ID21437051

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

6-[Difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline
6-{Difluor[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}chinolin [German] [ACD/IUPAC Name]
6-{Difluoro[6-(1-méthyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]méthyl}quinoléine [French] [ACD/IUPAC Name]
6-{Difluoro[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}quinoline [ACD/IUPAC Name]
943540-75-8 [RN]
JNJ-38877605
Quinoline, 6-[difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]- [ACD/Index Name]
[943540-75-8] [RN]
10374-51-3 [RN]
1072116-03-0 [RN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

15UDG410PN [DBID]
UNII:15UDG410PN [DBID]
UNII-15UDG410PN [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      c-Met/HGFR MedChem Express HY-50683
      JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases. MedChem Express
      JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.; IC50 value: 4 nM [1]; Target: c-Met; in vitro: JNJ-38877605 shows more than 600-fold selectivity for c-Met compared with more than 200 other diverse tyrosine and serine-threonine kinases and also potently inhibits HGF-stimulated and constitutively activated c-Met phosphorylation in vitro. MedChem Express HY-50683
      Protein Tyrosine Kinase/RTK MedChem Express HY-50683
      Protein Tyrosine Kinase/RTK; MedChem Express HY-50683

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.734
Molar Refractivity: 100.6±0.5 cm3
#H bond acceptors: 7
#H bond donors: 0
#Freely Rotating Bonds: 3
#Rule of 5 Violations: 0
ACD/LogP: 3.13
ACD/LogD (pH 5.5): 2.84
ACD/BCF (pH 5.5): 83.47
ACD/KOC (pH 5.5): 819.95
ACD/LogD (pH 7.4): 2.85
ACD/BCF (pH 7.4): 85.66
ACD/KOC (pH 7.4): 841.47
Polar Surface Area: 74 Å2
Polarizability: 39.9±0.5 10-24cm3
Surface Tension: 56.5±7.0 dyne/cm
Molar Volume: 251.2±7.0 cm3

Click to predict properties on the Chemicalize site


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