ChemSpider 2D Image | JZL-184 | C27H24N2O9

JZL-184

  • Molecular FormulaC27H24N2O9
  • Average mass520.487 Da
  • Monoisotopic mass520.148193 Da
  • ChemSpider ID21467840

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1101854-58-3 [RN]
1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 4-nitrophenyl ester [ACD/Index Name]
4-[Bis(1,3-benzodioxol-5-yl)(hydroxy)méthyl]-1-pipéridinecarboxylate de 4-nitrophényle [French] [ACD/IUPAC Name]
4-Nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]-1-piperidinecarboxylate [ACD/IUPAC Name]
4-Nitrophenyl-4-[bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]-1-piperidincarboxylat [German] [ACD/IUPAC Name]
7MZ1I2J68A
JZL-184
(4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
[1101854-58-3]
4-?NITROPHENYL-?4-?(DIBENZO[D][1,?3]DIOXOL-?5-?YL(HYDROXY)METHYL)PIPERIDINE-?1-?CARBOXYLATE
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  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      Sold under license from The Scripps Research Institute. Tocris Bioscience 3836
    • Bio Activity:

      Enzymes Tocris Bioscience 3836
      Hydrolases Tocris Bioscience 3836
      JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 ?M for inhibition of MAGL and FAAH in mouse brain membranes respectively.; IC50 value: 8 nM [1]; Target: MAGL inhibitor; in vitro: JZL184 prolongs DSE in Purkinje neurons in cerebellar slices and DSI in CA1 pyramidal neurons in hippocampal slices. MedChem Express HY-15249
      MAGL Tocris Bioscience 3836
      MAGL MedChem Express HY-15249
      MAGL inhibitor Tocris Bioscience 3836
      Metabolism/Protease MedChem Express HY-15249
      Metabolism/Protease; MedChem Express HY-15249
      Potent and selective MAGL inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM). Potentiates depolarization-induced suppression of excitability in cerebellar Purkinje neurons. Exhibits >300-fold selectivity for MAGL over FAAH in vitro. Attenuates nociception in neuropathic and inflammatory pain models. Also reduces free fatty aci d levels in primary tumors. Tocris Bioscience 3836
      Potent and selective MAGL inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM). Potentiates depolarization-induced suppression of excitability in cerebellar Purkinje neurons. Exhibits >300-fold selectivity for MAGL over FAAH in vitro. Attenuates nociception in neuropathic and inflammatory pain models. Also reduces free fatty acid levels in primary tumors. Tocris Bioscience 3836

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.5±0.1 g/cm3
Boiling Point: 706.4±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.4 mmHg at 25°C
Enthalpy of Vaporization: 108.5±3.0 kJ/mol
Flash Point: 381.0±32.9 °C
Index of Refraction: 1.661
Molar Refractivity: 131.0±0.3 cm3
#H bond acceptors: 11
#H bond donors: 1
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 3
ACD/LogP: 5.25
ACD/LogD (pH 5.5): 4.20
ACD/BCF (pH 5.5): 915.44
ACD/KOC (pH 5.5): 4587.08
ACD/LogD (pH 7.4): 4.20
ACD/BCF (pH 7.4): 915.44
ACD/KOC (pH 7.4): 4587.08
Polar Surface Area: 133 Å2
Polarizability: 51.9±0.5 10-24cm3
Surface Tension: 67.9±3.0 dyne/cm
Molar Volume: 354.6±3.0 cm3

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