ChemSpider 2D Image | Remodelin | C15H14N4S

Remodelin

  • Molecular FormulaC15H14N4S
  • Average mass282.363 Da
  • Monoisotopic mass282.093903 Da
  • ChemSpider ID23306946

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

4-[2-(2-Cyclopentylidenehydrazino)-1,3-thiazol-4-yl]benzonitrile [ACD/IUPAC Name]
4-[2-(2-Cyclopentylidènehydrazino)-1,3-thiazol-4-yl]benzonitrile [French] [ACD/IUPAC Name]
4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
4-[2-(2-Cyclopentylidenhydrazino)-1,3-thiazol-4-yl]benzonitril [German] [ACD/IUPAC Name]
949912-58-7 [RN]
Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]- [ACD/Index Name]
Remodelin
4-(2-(2-cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile
4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile
4-[2-(N'-cyclopentylidene-hydrazino)-thiazol-4-yl]-benzonitrile
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
PubChem Substance ID 329825761 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Cell Cycle/DNA Damage; MedChem Express HY-16706
      Enzymes Tocris Bioscience 5193
      HDAC MedChem Express HY-16706
      N-acetyltransferase 10 (NAT10) inhibitor Tocris Bioscience 5193
      N-acetyltransferase 10 (NAT10) inhibitor. Improves nuclear shape in HGPS (Hutchinson-Gilford progeria syndrome) cells and lamin A/C depleted cells. Tocris Bioscience 5193
      Other Transferases Tocris Bioscience 5193
      Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10. MedChem Express
      Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.;IC50 value:;Target: NAT10 inhibitorRemodelin can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging. MedChem Express HY-16706
      Transferases Tocris Bioscience 5193

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 498.9±47.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.3 mmHg at 25°C
Enthalpy of Vaporization: 76.7±3.0 kJ/mol
Flash Point: 255.5±29.3 °C
Index of Refraction: 1.702
Molar Refractivity: 82.9±0.5 cm3
#H bond acceptors: 4
#H bond donors: 1
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 0
ACD/LogP: 2.16
ACD/LogD (pH 5.5): 2.82
ACD/BCF (pH 5.5): 81.55
ACD/KOC (pH 5.5): 811.47
ACD/LogD (pH 7.4): 2.82
ACD/BCF (pH 7.4): 81.90
ACD/KOC (pH 7.4): 814.92
Polar Surface Area: 89 Å2
Polarizability: 32.9±0.5 10-24cm3
Surface Tension: 55.9±7.0 dyne/cm
Molar Volume: 214.0±7.0 cm3

Click to predict properties on the Chemicalize site


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