ChemSpider 2D Image | NMS-P715 | C35H39F3N8O3

NMS-P715

  • Molecular FormulaC35H39F3N8O3
  • Average mass676.731 Da
  • Monoisotopic mass676.309692 Da
  • ChemSpider ID25058553

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1202055-32-0 [RN]
1H-Pyrazolo[4,3-h]quinazoline-3-carboxamide, N-(2,6-diethylphenyl)-4,5-dihydro-1-methyl-8-[[4-[[(1-methyl-4-piperidinyl)amino]carbonyl]-2-(trifluoromethoxy)phenyl]amino]- [ACD/Index Name]
N-(2,6-Diethylphenyl)-1-methyl-8-({4-[(1-methyl-4-piperidinyl)carbamoyl]-2-(trifluormethoxy)phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-h]chinazolin-3-carboxamid [German] [ACD/IUPAC Name]
N-(2,6-Diethylphenyl)-1-methyl-8-({4-[(1-methyl-4-piperidinyl)carbamoyl]-2-(trifluoromethoxy)phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide [ACD/IUPAC Name]
N-(2,6-Diéthylphényl)-1-méthyl-8-({4-[(1-méthyl-4-pipéridinyl)carbamoyl]-2-(trifluorométhoxy)phényl}amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide [French] [ACD/IUPAC Name]
N-(2,6-Diethylphenyl)-1-Methyl-8-({4-[(1-Methylpiperidin-4-Yl)carbamoyl]-2-(Trifluoromethoxy)phenyl}amino)-4,5-Dihydro-1h-Pyrazolo[4,3-H]quinazoline-3-Carboxamide
NMS-P715
1202055-34-2 [RN]
MFCD19443684
MPS1 Inhibitor, NMS-P715 - Calbiochem
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1202055-32-0/1202055-34-2 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Cell Cycle/DNA Damage MedChem Express HY-12382
      Cell Cycle/DNA Damage; MedChem Express HY-12382
      Mps1 MedChem Express HY-12382
      NMS-P715 is the first selective, ATP-competitive and orally bioavailable MPS1 small-molecule inhibitor(IC50=8 nM); selectively reduces cancer cell proliferation, leaving normal cells almost unaffected . MedChem Express
      NMS-P715 is the first selective, ATP-competitive and orally bioavailable MPS1 small-molecule inhibitor(IC50=8 nM); selectively reduces cancer cell proliferation, leaving normal cells almost unaffected.; IC50 value: 8 nM (compound preincubation) [1]; Target: MPS1 inhibitor; NMS-P715 was found to be highly specific for MPS1, with no other kinases inhibited below an IC50 value of 5 mmol/L and with only 3 kinases inhibited below 10 mmol/L (CK2, MELK, and NEK6), which were not significantly affected by compound preincubation. MedChem Express HY-12382
      NMS-P715 is the first selective, ATP-competitive and orally bioavailable MPS1 small-molecule inhibitor(IC50=8 nM); selectively reduces cancer cell proliferation, leaving normal cells almost unaffected.;IC50 value: 8 nM (compound preincubation) [1];Target: MPS1 inhibitorNMS-P715 was found to be highly specific for MPS1, with no other kinases inhibited below an IC50 value of 5 mmol/L and with only 3 kinases inhibited below 10 mmol/L (CK2, MELK, and NEK6), which were not significantly affected by compound preincubation. NMS-P715 promotes massive SAC override with a half-maximal effective concentration (EC50) of 65 nmol/L.NMS-P715 accelerates mitosis and affects kinetochore components localization causing massive aneuploidy and cell death in a variety of tumoral cell lines and inhibits tumor growth in preclinical cancer models. MedChem Express HY-12382

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.652
Molar Refractivity: 177.3±0.5 cm3
#H bond acceptors: 11
#H bond donors: 3
#Freely Rotating Bonds: 10
#Rule of 5 Violations: 2
ACD/LogP: 4.72
ACD/LogD (pH 5.5): 1.79
ACD/BCF (pH 5.5): 2.83
ACD/KOC (pH 5.5): 11.54
ACD/LogD (pH 7.4): 3.34
ACD/BCF (pH 7.4): 101.59
ACD/KOC (pH 7.4): 414.18
Polar Surface Area: 126 Å2
Polarizability: 70.3±0.5 10-24cm3
Surface Tension: 48.5±7.0 dyne/cm
Molar Volume: 484.9±7.0 cm3

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