ChemSpider 2D Image | as1949490 | C20H18ClNO2S

as1949490

  • Molecular FormulaC20H18ClNO2S
  • Average mass371.880 Da
  • Monoisotopic mass371.074677 Da
  • ChemSpider ID25069965

  • defined stereocentres - 1 of 1 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1203680-76-5 [RN]
2-Thiophenecarboxamide, 3-[(4-chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]- [ACD/Index Name]
3-[(4-Chlorbenzyl)oxy]-N-[(1S)-1-phenylethyl]-2-thiophencarboxamid [German] [ACD/IUPAC Name]
3-[(4-Chlorobenzyl)oxy]-N-[(1S)-1-phenylethyl]-2-thiophenecarboxamide [ACD/IUPAC Name]
3-[(4-Chlorobenzyl)oxy]-N-[(1S)-1-phényléthyl]-2-thiophènecarboxamide [French] [ACD/IUPAC Name]
as1949490
AS-1949490
(S)-3-((4-chlorobenzyl)oxy)-N-(1-phenylethyl)thiophene-2-carboxamide
[1203680-76-5] [RN]
1,6-Naphthyridin-5-amine [ACD/Index Name] [ACD/IUPAC Name]
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Enzymes Tocris Bioscience 3718
      Inositol Phosphatases Tocris Bioscience 3718
      Phosphatases Tocris Bioscience 3718
      Selective SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2) inhibitor (IC50 values are 0.34 ?M and 0.62 ?M for mouse and human respectively); displays approximately 30-fold affinity for SHIP2 ov er SHIP1. Increases insulin-induced phosphorylation of Akt in L6 myotubules. Stimulates activation of glucose metabolism; regulates gluconeogenesis in vitro and in vivo and exhibits antidiabetic effec ts. Tocris Bioscience 3718
      Selective SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2) inhibitor (IC50 values are 0.34 ?M and 0.62 ?M for mouse and human respectively); displays approximately 30-fold affinity for SHIP2 over SHIP1. Increases insulin-induced phosphorylation of Akt in L6 myotubules. Stimulates activation of glucose metabolism; regulates gluconeogenesis in vitro and in vivo and exhibits antidiabetic effects. Tocris Bioscience 3718
      Selective SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2) inhibitor (IC50 values are 0.34 muM and 0.62 muM for mouse and human respectively); displays approximately 30-fold affinity for SHIP2 over SHIP1. Increases insulin-induced phosphorylation of Akt in L6 myotubules. Stimulates activation of glucose metabolism; regulates gluconeogenesis in vitro and in vivo and exhibits antidiabetic effects. Tocris Bioscience 3718
      SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) inhibitor Tocris Bioscience 3718

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 553.7±50.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.5 mmHg at 25°C
Enthalpy of Vaporization: 83.5±3.0 kJ/mol
Flash Point: 288.7±30.1 °C
Index of Refraction: 1.622
Molar Refractivity: 103.4±0.3 cm3
#H bond acceptors: 3
#H bond donors: 1
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 1
ACD/LogP: 5.20
ACD/LogD (pH 5.5): 5.09
ACD/BCF (pH 5.5): 4330.48
ACD/KOC (pH 5.5): 13951.65
ACD/LogD (pH 7.4): 5.09
ACD/BCF (pH 7.4): 4330.48
ACD/KOC (pH 7.4): 13951.65
Polar Surface Area: 67 Å2
Polarizability: 41.0±0.5 10-24cm3
Surface Tension: 49.3±3.0 dyne/cm
Molar Volume: 293.9±3.0 cm3

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