ChemSpider 2D Image | Omacetaxine mepesuccinate | C29H39NO9

Omacetaxine mepesuccinate

  • Molecular FormulaC29H39NO9
  • Average mass545.621 Da
  • Monoisotopic mass545.262512 Da
  • ChemSpider ID251215
  • defined stereocentres - 4 of 4 defined stereocentres


More details:



Featured data source



Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Omacetaxine mepesuccinate [INN] [USAN] [Wiki]
(-)-homoharringtonine
26833-87-4 [RN]
8885
Ceflatonin [Trade name]
Cephalotaxine, O3-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methyl-1-oxoheptyl]- [ACD/Index Name]
Homoharringtonine
mépésuccinate d’omacétaxine [French] [INN]
mepesuccinato de omacetaxina [Spanish] [INN]
Myelostat [Trade name]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

6FG8041S5B [DBID]
CGX-635 [DBID]
nchembio.2007.59-comp6 [DBID]
NCI60_000917 [DBID]
NSC141633 [DBID]
NSC-141633 [DBID]
UNII:6FG8041S5B [DBID]
UNII-6FG8041S5B [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Chemical Class:

      A cephalotaxine-derived alkaloid ester obtained from <ital>Cephalotaxus harringtonia</ital>; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia. ChEBI CHEBI:71019
    • Bio Activity:

      Cell Biology Tocris Bioscience 1416
      Cell Metabolism Tocris Bioscience 1416
      DNA, RNA and Protein Synthesis Tocris Bioscience 1416
      Homoharringtonine(HHT) is a cytotoxic alkaloid from the evergreen tree. MedChem Express
      Homoharringtonine(HHT) is a cytotoxic alkaloid from the evergreen tree.; Target: Others; Homoharringtonine (HHT) is a cephalotaxine alkaloid with reported efficacy in acute myelogenous leukemia (AML). MedChem Express HY-14944
      Homoharringtonine(HHT) is a cytotoxic alkaloid from the evergreen tree.;Target: Homoharringtonine (HHT) is a cephalotaxine alkaloid with reported efficacy in acute myelogenous leukemia (AML). HHT is well tolerated, but with unique problems associated with administration. It has demonstrable efficacy in pre-treated patients with AML, but its role in the treatment of this disease remains to be defined [1]. HHT has been investigated alone and in combination with interferon-alpha and low-dose cytarabine in late and early chronic phases, with positive results. Additional areas of interest include the potential use of HHT for the treatment of central nervous system leukemia, polycythemia vera, and other nonmalignant conditions such as malaria. New semisynthetic preparations and HHT derivatives that bypass multidrug resistance may improve the efficacy and toxicity profiles, and broaden the range of antitumor efficacy [2]. HHT, one of the alkaloids from a Chinese natural plant, Cepha MedChem Express HY-14944
      Inhibitor of protein synthesis. Antileukemic agent Tocris Bioscience 1416
      Inhibitor of protein synthesis. Blocks elongation phase of translation by binding to the 60-S ribosome subunit. Antileukemic. Tocris Bioscience 1416
      Others MedChem Express HY-14944

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.3±0.1 g/cm3
Boiling Point: 713.1±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.4 mmHg at 25°C
Enthalpy of Vaporization: 109.5±3.0 kJ/mol
Flash Point: 385.1±32.9 °C
Index of Refraction: 1.605
Molar Refractivity: 140.6±0.4 cm3
#H bond acceptors: 10
#H bond donors: 2
#Freely Rotating Bonds: 11
#Rule of 5 Violations: 2
ACD/LogP: 2.70
ACD/LogD (pH 5.5): 1.34
ACD/BCF (pH 5.5): 3.65
ACD/KOC (pH 5.5): 47.88
ACD/LogD (pH 7.4): 2.23
ACD/BCF (pH 7.4): 28.35
ACD/KOC (pH 7.4): 371.63
Polar Surface Area: 124 Å2
Polarizability: 55.7±0.5 10-24cm3
Surface Tension: 61.3±5.0 dyne/cm
Molar Volume: 408.4±5.0 cm3

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