ChemSpider 2D Image | (3E)-N-(3-Chlorophenyl)-3-({3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl}methylene)-N-methyl-2-oxo-5-indolinesulfonamide | C28H30ClN5O4S

(3E)-N-(3-Chlorophenyl)-3-({3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl}methylene)-N-methyl-2-oxo-5-indolinesulfonamide

  • Molecular FormulaC28H30ClN5O4S
  • Average mass568.087 Da
  • Monoisotopic mass567.170715 Da
  • ChemSpider ID25991510

  • Double-bond stereo - Double-bond stereo

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(3E)-N-(3-Chlorophenyl)-3-({3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl}methylene)-N-methyl-2-oxo-5-indolinesulfonamide [ACD/IUPAC Name]
(3E)-N-(3-Chlorophényl)-3-({3,5-diméthyl-4-[(4-méthyl-1-pipérazinyl)carbonyl]-1H-pyrrol-2-yl}méthylène)-N-méthyl-2-oxo-5-indolinesulfonamide [French] [ACD/IUPAC Name]
(3E)-N-(3-Chlorphenyl)-3-({3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl}methylen)-N-methyl-2-oxo-5-indolinsulfonamid [German] [ACD/IUPAC Name]
1H-Indole-5-sulfonamide, N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-, (3E)- [ACD/Index Name]
(E)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxoindoline-5-sulfonamide
658084-23-2 [RN]
Met Kinase Inhibitor
N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-,(3Z)-1H-Indole-5-sulfonamide
N-(3-CHLOROPHENYL)-3-{[3,5-DIMETHYL-4-(4-METHYLPIPERAZINE-1-CARBONYL)-1H-PYRROL-2-YL]METHYLIDENE}-N-METHYL-2-OXO-1H-INDOLE-5-SULFONAMIDE
N-(3-Chlorophenyl)-N-methyl-3-[[3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

SU-11274 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      c-Met/HGFR MedChem Express HY-12014
      Protein Tyrosine Kinase/RTK MedChem Express HY-12014
      Protein Tyrosine Kinase/RTK; MedChem Express HY-12014
      SU11274(PKI-SU11274) is a selective Met inhibitor with IC50 of 10 nM, no effects on PGDFR?, EGFR or Tie2.; IC50 value: 10 nM [1]; Target: Met; in vitro: SU11274 exhibits greater than 50-fold selectivity for Met versus Flk and more than 500 times selectivity versus other tyrosine kinases such as FGFR-1, c-src, PDGFbR, and EGFR. MedChem Express HY-12014

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.664
Molar Refractivity: 150.4±0.4 cm3
#H bond acceptors: 9
#H bond donors: 2
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 1
ACD/LogP: 2.15
ACD/LogD (pH 5.5): 1.38
ACD/BCF (pH 5.5): 3.16
ACD/KOC (pH 5.5): 33.35
ACD/LogD (pH 7.4): 2.60
ACD/BCF (pH 7.4): 53.01
ACD/KOC (pH 7.4): 559.38
Polar Surface Area: 114 Å2
Polarizability: 59.6±0.5 10-24cm3
Surface Tension: 63.3±3.0 dyne/cm
Molar Volume: 405.5±3.0 cm3

Click to predict properties on the Chemicalize site


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